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Discerning Primary and Secondary Factors Responsible for Clinical Fatigue in Multisystem Diseases

Department of Molecular Physiology & Biophysics, University of Vermont, Burlington, VT 05405, USA
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Biology 2014, 3(3), 606-622; https://doi.org/10.3390/biology3030606
Received: 27 June 2014 / Revised: 21 August 2014 / Accepted: 1 September 2014 / Published: 22 September 2014
(This article belongs to the Special Issue Muscle Structure and Function)
Fatigue is a common symptom of numerous acute and chronic diseases, including myalgic encephalomyelitis/chronic fatigue syndrome, multiple sclerosis, heart failure, cancer, and many others. In these multi-system diseases the physiological determinants of enhanced fatigue encompass a combination of metabolic, neurological, and myofibrillar adaptations. Previous research studies have focused on adaptations specific to skeletal muscle and their role in fatigue. However, most have neglected the contribution of physical inactivity in assessing disease syndromes, which, through deconditioning, likely contributes to symptomatic fatigue. In this commentary, we briefly review disease-related muscle phenotypes in the context of whether they relate to the primary disease or whether they develop secondary to reduced physical activity. Knowledge of the etiology of the skeletal muscle adaptations in these conditions and their contribution to fatigue symptoms is important for understanding the utility of exercise rehabilitation as an intervention to alleviate the physiological precipitants of fatigue. View Full-Text
Keywords: muscular fatigue; multi-system diseases; muscle deconditioning; chronic fatigue syndrome; multiple sclerosis; cancer; heart failure muscular fatigue; multi-system diseases; muscle deconditioning; chronic fatigue syndrome; multiple sclerosis; cancer; heart failure
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Maughan, D.; Toth, M. Discerning Primary and Secondary Factors Responsible for Clinical Fatigue in Multisystem Diseases. Biology 2014, 3, 606-622.

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