Special Issue "Multidisciplinary Insights on Bone Healing"
Deadline for manuscript submissions: closed (1 February 2021).
Interests: bioceramics based bone grafting materials for regenerative biomedicine; bioceramics biocompatibility through in vitro/cytotoxicity assays, and /in vivo /implantation in animal model; bone cutting device evaluation, both for rotatory instruments and piezosurgical osteotomes; microsurgical flap reconstruction for head & neck defects; head & neck surgical oncology
Interests: effects of physical energy applied to biological systems, in particular evaluation of the effects of pulsed electromagnetic fields and ultrasound on bone tissue and cartilage in animal models in vivo; histomorphometry and histology on bone; cartilage and teeth; effect of drugs on bone metabolism; bone regeneration in implant dentistry and surgery
At the basis of the bone healing process there is a sophisticated multifactorial “system” composed of both macro- and microscopic agents that interact each other in order to obtain a recovery of the correct morphological and functional features. Bone-tissue-specific agents and extra-bone factors can influence the final outcome at several levels; all of them are characterized by complex and multidisciplinary perspectives that have raised many questions that have yet to be fully elucidated. The consequence has been the raising of the curtain on this fascinating topic, which must be looked at from different angles in order to be correctly framed.
Basic research with a transitional approach and clinical applications about the bone healing process are manifold: fracture can be either iatrogenic (antiresorptive therapies) or spontaneous, involving a healthy or an impaired bone; moreover, adequate bone healing of osteotomic surfaces is essential in several surgical specialties. Interdisciplinarity between pre-clinical (e.g., the interaction of tissue and biophysical energy), medical (e.g., innovative pharmacological protocols) and surgical specialties, as well as regenerative medicine strategies, may result in a common enrichment in terms of knowledge of bone healing processes and an improvement in applying these notions for the safety of patients. We hope that researchers with different areas of expertise will consider contributing to this Special Issue.
Dr. Alexandre Anesi
Dr. Francesco Cavani
Manuscript Submission Information
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- bone healing
- bone regeneration
- bone diseases and related pathologies
- bone tissue engineering
- bone substitute