Biosensing Applications and Cancer Cell Diagnosis/Treatment

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: closed (1 March 2021) | Viewed by 5297

Special Issue Editors


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Guest Editor
Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585 Singapore
Interests: biosensing; nanostructures; optical materials; cancer therapy; diagnosis
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Faculty of Science, Agriculture and Engineering (SAgE), Newcastle University, Singapore
Interests: bioinspired materials; multifunctional nanostructures; biosensors and bioimaging; theranostic nanomaterials; nanomedicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Nanostructures (colloidal and planar) are being studied extensively for developing a wide range of biosensors and theranostic applications. The unique properties of nanostructures (optical, electrical, catalytic, etc.) enable the design of ultrasensitive diagnostic tools for the detection of a wide variety of bio-analytes, including but not limited to small molecules, toxic metal ions, oligonucleotides (i.e., DNAs, RNAs), proteins, as well as microorganisms such as viruses, bacteria, and cells.

In recent years, biosensors and advanced theranostic materials have been explored extensively. The progress in this field has been substantial and has led to several complicated applications, where traditional techniques are either not useful or available. In light of the recent research and development, the exploration of new materials and nanostructures for developing biosensors, diagnostic tools, and theranostic technologies is becoming more popular in the biomedical market.   

This Special Issue will publish novel, high-quality, original research articles as well as critical reviews/tutorial reviews/short communications focused on developing novel biosensing and theranostic technologies. We invite researchers, professors, medical practitioners, and scientists from the academic community as well as industrial sectors and hospitals to contribute their novel publishable works to this Special Issue. 

Possible topics include, but are not limited to:

  • Advanced materials for sensing applications;
  • New approaches for diagnosis of diseases and disorders;
  • Novel materials for developing non-invasive therapeutic techniques (e.g., photodynamic therapy, photothermal therapy, etc.);
  • Fundamentals of non-invasive techniques for cancer therapy;
  • Multifunctional nanomaterials for theranostic applications;
  • Microfluidics and lab-on-chip applications.

Dr. Mohammad Tavakkoli Yaraki
Prof. Dr. Yen Nee Tan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Possible topics include, but are not limited to:
  • Advanced materials for sensing applications;
  • New approaches for diagnosis of diseases and disorders;
  • Novel materials for developing non-invasive therapeutic techniques (e.g., photodynamic therapy, photothermal therapy, etc.);
  • Fundamentals of non-invasive techniques for cancer therapy;
  • Multifunctional nanomaterials for theranostic applications;
  • Microfluidics and lab-on-chip applications.
  • Biofunctionalization for targeted therapy and sensing
  • Bioimaging probes and medical applications
  • Nanoparticles-based biosensors
  • Cancer biology and drug screening

Published Papers (1 paper)

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Research

29 pages, 5291 KiB  
Article
Preparation, Optimization and In-Vitro Evaluation of Curcumin-Loaded Niosome@calcium Alginate Nanocarrier as a New Approach for Breast Cancer Treatment
by Iman Akbarzadeh, Mona Shayan, Mahsa Bourbour, Maryam Moghtaderi, Hassan Noorbazargan, Faten Eshrati Yeganeh, Samaneh Saffar and Mohammadreza Tahriri
Biology 2021, 10(3), 173; https://doi.org/10.3390/biology10030173 - 26 Feb 2021
Cited by 56 | Viewed by 4880
Abstract
Cancer is one of the most common causes of mortality, and its various treatment methods can have many challenges for patients. As one of the most widely used cancer treatments, chemotherapy may result in diverse side effects. The lack of targeted drug delivery [...] Read more.
Cancer is one of the most common causes of mortality, and its various treatment methods can have many challenges for patients. As one of the most widely used cancer treatments, chemotherapy may result in diverse side effects. The lack of targeted drug delivery to tumor tissues can raise the possibility of damage to healthy tissues, with attendant dysfunction. In the present study, an optimum formulation of curcumin-loaded niosomes with a calcium alginate shell (AL-NioC) was developed and optimized by a three-level Box–Behnken design—in terms of dimension and drug loading efficiency. The niosomes were characterized by transmission electron microscopy, Fourier-transform infrared spectroscopy, and dynamic light scattering. The as-formulated niosomes showed excellent stability for up to 1 month at 4 °C. Additionally, the niosomal formulation demonstrated a pH-dependent release; a slow-release profile in physiological pH (7.4), and a more significant release rate at acidic conditions (pH = 3). Cytotoxicity studies showed high compatibility of AL-NioC toward normal MCF10A cells, while significant toxicity was observed in MDA-MB-231 and SKBR3 breast cancer cells. Gene expression studies of the cancer cells showed downregulation of Bcl2, cyclin D, and cyclin E genes, as well as upregulation of P53, Bax, caspase-3, and caspase-9 genes expression following the designed treatment. Flow cytometry studies confirmed a significant enhancement in the apoptosis rate in the presence of AL-NioC in both MDA-MB-231 and SKBR3 cells as compared to other samples. In general, the results of this study demonstrated that—thanks to its biocompatibility toward normal cells—the AL-NioC formulation can efficiently deliver hydrophobic drugs to target cancer cells while reducing side effects. Full article
(This article belongs to the Special Issue Biosensing Applications and Cancer Cell Diagnosis/Treatment)
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