Special Issue "Plant Functional Genomics in the Era of Omics Approaches"

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Genetics and Genomics".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editors

Dr. Mariateresa Volpicella
E-Mail Website
Guest Editor
Department of Biosciences, Biotechnology and Biopharmaceutic, Università degli Studi di Bari, Bari, Italy
Interests: plant molecular biology; NGS approaches; metagenomics and functional genomics
Prof. Dr. Cinzia Montemurro
E-Mail Website
Guest Editor
Department of Soil, Plants and Food Sciences, Faculty of Agricultural Science, University of Bari “Aldo Moro,” Bari, Italy
Interests: Genotyping by sequencing; olive germplasm; grapevine; genetic diversity; functional genomics; molecular polymorphism
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, omics approaches have offered an extraordinary opportunity to identify and measure a huge number of genes and proteins that play a crucial role in the regulation of several plant cellular processes. The availability of the entire genome from model plants, such as Arabidopsis thaliana and rice, lays the foundations for understanding and assigning functions to unknown genes, using different and multiparallel approaches. Indeed, comparative genome analysis is actually a powerful approach, which is useful in the identification of gene functions associated with plant metabolic processes and development. In this perspective, all the data derived from transcriptomics, proteomics and metabolomics studies allow the investigation of the intricate network of relationships between biomolecules within the plant system.

This Special Issue welcomes the submission of original research and review manuscripts focusing on plant functional genomic studies, including methods and developments that have made contributions to field development.

Dr. Mariateresa Volpicella
Prof. Dr. Cinzia Montemurro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant systems biology
  • gene expression
  • transcriptomics
  • proteomics
  • metabolomics
  • functional genomics

Published Papers (1 paper)

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Research

Article
Targeting Penicillium expansum GMC Oxidoreductase with High Affinity Small Molecules for Reducing Patulin Production
Biology 2021, 10(1), 21; https://doi.org/10.3390/biology10010021 - 31 Dec 2020
Viewed by 605
Abstract
Flavine adenine dinucleotide (FAD) dependent glucose methanol choline oxidoreductase (GMC oxidoreductase) is the terminal key enzyme of the patulin biosynthetic pathway. GMC oxidoreductase catalyzes the oxidative ring closure of (E)-ascladiol to patulin. Currently, no protein involved in the patulin biosynthesis in [...] Read more.
Flavine adenine dinucleotide (FAD) dependent glucose methanol choline oxidoreductase (GMC oxidoreductase) is the terminal key enzyme of the patulin biosynthetic pathway. GMC oxidoreductase catalyzes the oxidative ring closure of (E)-ascladiol to patulin. Currently, no protein involved in the patulin biosynthesis in Penicillium expansum has been experimentally characterized or solved by X-ray diffraction. Consequently, nothing is known about P. expansum GMC oxidoreductase substrate-binding site and mode of action. In the present investigation, a 3D comparative model for P. expansum GMC oxidoreductase has been described. Furthermore, a multistep computational approach was used to identify P. expansum GMC oxidoreductase residues involved in the FAD binding and in substrate recognition. Notably, the obtained 3D comparative model of P. expansum GMC oxidoreductase was used for performing a virtual screening of a chemical/drug library, which allowed to predict new GMC oxidoreductase high affinity ligands to be tested in in vitro/in vivo assays. In vitro assays performed in presence of 6-hydroxycoumarin and meticrane, among the highly affinity predicted binders, confirmed a dose-dependent inhibition (17–81%) of patulin production by 6-hydroxycoumarin (10 µM–1 mM concentration range), whereas the approved drug meticrane inhibited patulin production by 43% already at 10 µM. Furthermore, 6-hydroxycoumarin and meticrane caused a 60 and 41% reduction of patulin production, respectively, in vivo on apples at 100 µg/wound. Full article
(This article belongs to the Special Issue Plant Functional Genomics in the Era of Omics Approaches)
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