Special Issue "Natural Products and Herbal Drugs as Immunomodulating Agents"

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: 30 April 2021.

Special Issue Editors

Dr. Marco Biagi
Guest Editor
Department of Physical Sciences, Earth and Environment, University of Siena, Siena, Italy
Interests: medicinal plants; pharmaceutical biology; phytochemistry; phytotherapy
Dr. José Maurício Sforcin
Guest Editor
Institute of Biosciences, São Paulo State University, Botucatu 18618-691, Brazil
Interests: natural products; bee products; propolis; immunomodulation

Special Issue Information

Dear Colleagues,

The importance and also the complexity of the human immune system is largely known. Currently, its multifaceted defencing role, its wide connections with the central nervous and the endocrine system, and the recent discover of new intracellular pathways have made it a very fascinating and multidisciplinary area of scientific research. The modulation of the immune response has a long and crucial history in medicine, biology, biotechnology, and pharmacology, since it has helped to strengthen and regulate defensive systems, from vaccination through to the development of specific and nonspecific drugs. Natural products could be undoubtedly considered as important immunomodulating agents; indeed, they have been the main source of  lead compounds in drug discovery, and their use is deemed relevant in the ethnobotany of many different countries; in many medicine systems such as Traditional Chinese Medicine and Ayurveda; and in conventional Western medicine, as claimed by official monographs on medicinal plants issued by World Health Organizations and by European Medicines Agency. This Special Issue focuses on the recent advances and latest research on natural products targeting the immune response. Original articles related to interactions between pathogens and the innate and adaptive responses modulated by natural products, isolated compounds, and phytocomplex of herbal drugs are welcome. Papers describing the role of natural products in the crosstalk between the immune system and other biological processes as well as works focusing on natural products as adjuvant compounds are also warmly welcome. All papers are asked to explore cellular and molecular mechanisms, linking biological activity to the chemical composition of the natural product. High quality and innovative in vitro methods are endorsed, as well as validated network pharmacology and in silico approaches. Only ethically well documented in vivo studies will be considered, and comprehensive reviews will be also accepted as well. 

Dr. Marco Biagi
Dr. José Maurício Sforcin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Natural products
  • Bee products
  • Herbal drugs
  • Immunomodulation
  • Immune system
  • Pharmaceutical biology

Published Papers

This special issue is now open for submission.
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