Natural Products and Herbal Drugs as Immunomodulating Agents

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 3732

Special Issue Editors


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Guest Editor
Department of Physical Sciences, Earth and Environment, University of Siena, Siena, Italy
Interests: medicinal plants; pharmaceutical biology; phytochemistry; phytotherapy
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Institute of Biosciences, São Paulo State University, Botucatu 18618-691, Brazil
Interests: natural products; bee products; propolis; immunomodulation

Special Issue Information

Dear Colleagues,

The importance and also the complexity of the human immune system is largely known. Currently, its multifaceted defencing role, its wide connections with the central nervous and the endocrine system, and the recent discover of new intracellular pathways have made it a very fascinating and multidisciplinary area of scientific research. The modulation of the immune response has a long and crucial history in medicine, biology, biotechnology, and pharmacology, since it has helped to strengthen and regulate defensive systems, from vaccination through to the development of specific and nonspecific drugs. Natural products could be undoubtedly considered as important immunomodulating agents; indeed, they have been the main source of  lead compounds in drug discovery, and their use is deemed relevant in the ethnobotany of many different countries; in many medicine systems such as Traditional Chinese Medicine and Ayurveda; and in conventional Western medicine, as claimed by official monographs on medicinal plants issued by World Health Organizations and by European Medicines Agency.

This Special Issue focuses on the recent advances and latest research on natural products targeting the immune response. Original articles related to interactions between pathogens and the innate and adaptive responses modulated by natural products, isolated compounds, and phytocomplex of herbal drugs are welcome. Papers describing the role of natural products in the crosstalk between the immune system and other biological processes as well as works focusing on natural products as adjuvant compounds are also warmly welcome. All papers are asked to explore cellular and molecular mechanisms, linking biological activity to the chemical composition of the natural product. High quality and innovative in vitro methods are endorsed, as well as validated network pharmacology and in silico approaches. Only ethically well documented in vivo studies will be considered, and comprehensive reviews will be also accepted as well. 

Dr. Marco Biagi
Dr. José Maurício Sforcin
Guest Editors

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Keywords

  • Natural products
  • Bee products
  • Herbal drugs
  • Immunomodulation
  • Immune system
  • Pharmaceutical biology

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Published Papers (1 paper)

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Research

15 pages, 3572 KiB  
Article
Genistein Sensitizes Human Cholangiocarcinoma Cell Lines to Be Susceptible to Natural Killer Cells
by Chutipa Chiawpanit, Suthida Panwong, Nunghathai Sawasdee, Pa-thai Yenchitsomanus and Aussara Panya
Biology 2022, 11(8), 1098; https://doi.org/10.3390/biology11081098 - 23 Jul 2022
Cited by 8 | Viewed by 2843
Abstract
Cholangiocarcinoma (CCA) is a lethal bile duct cancer, which has poor treatment outcomes due to its high resistance to chemotherapy and cancer recurrence. Activation of aberrant anti-apoptotic signaling pathway has been reported to be a mechanism of chemoresistance and immune escape of CCA. [...] Read more.
Cholangiocarcinoma (CCA) is a lethal bile duct cancer, which has poor treatment outcomes due to its high resistance to chemotherapy and cancer recurrence. Activation of aberrant anti-apoptotic signaling pathway has been reported to be a mechanism of chemoresistance and immune escape of CCA. Therefore, reversal of anti-apoptotic signaling pathway represents a feasible approach to potentiate effective treatments, especially for CCA with high chemoresistance. In this study, we demonstrated the effects of genistein on reactivation of apoptosis cascade and increase the susceptibility of CCA cells to natural killer (NK-92) cells. Genistein at 50 and 100 µM significantly activated extrinsic apoptotic pathway in CCA cells (KKU055, KKU100, and KKU213A), which was evident by reduction of procaspase-8 and -3 expression. Pretreatment of CCA cells with genistein at 50 µM, but not NK-92 cells, significantly increased NK-92 cell killing ability over the untreated control, suggesting the ability of genistein to sensitize CCA cells. Interestingly, genistein treatment could greatly lower the expression of cFLIP, an anti-apoptotic protein involved in the immune escape pathway, in addition to upregulation of death receptors, Fas- and TRAIL-receptors, in CCA cells, which might be the underlying molecular mechanism of genistein to sensitize CCA to be susceptible to NK-92 cells. Taken together, this finding revealed the benefit of genistein as a sensitizer to enhance the efficiency of NK cell immunotherapy for CCA. Full article
(This article belongs to the Special Issue Natural Products and Herbal Drugs as Immunomodulating Agents)
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