Mitochondrial Dynamics and Function
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cell Biology".
Deadline for manuscript submissions: closed (15 May 2023) | Viewed by 3525
Special Issue Editors
Interests: mitochondria; oxidative stress; autophagy; apoptosis; inflammation; mitochondrial disease
Interests: animal stress; cell biology; gene function; bioinformatics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondria are highly dynamic organelles that constantly undergo fission and fusion events, referred to as mitochondrial dynamics, to maintain their shape, number and size, as well as subcellular distribution. Mitochondrial fission allows the division of one mitochondrion into two daughter mitochondria by recruiting dynamin-related protein, whereas mitochondrial fusion is the union of two mitochondria resulting in one mitochondria by coordinating mitofusin1/2 and optic atrophy 1 (OPA1). Mitochondrial dynamics is associated with various cellular processes, including cell cycle, cell metabolism, apoptosis, mitophagy, cell proliferation and reactive oxygen species (ROS) production. Mitochondrial fission is critical for mitophagy to remove the misfolded proteins or mutated DNA from mitochondria, abnormal fission and mitophagy could induce the accumulation of dysfunctional mitochondria in cells. Defects in mitochondrial dynamics are correlated with many human diseases, including cancer, neurodegenerative disease, aging and infertility. Thus, regulators of mitochondrial homeostasis, biogenesis and function have evolved as promising novel targets for the treatment of mitochondrial dysfunction-associated diseases.
This Special Issue aims to collect original research and review articles to understand the physiological, metabolic, and cellular mechanisms that characterize the interaction between mitochondrial regulatory factors and the occurrence of diseases.
Prof. Dr. Xing Duan
Dr. Kun-Lin Chen
Dr. Yizeng Li
Guest Editors
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Keywords
- mitochondrial function
- oxidative stress
- autophagy
- apoptosis
- aging
- obesity
- diabetes mellitus
- infertility
- cancer
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