Challenges in Process Analytical Technologies for Mammalian Cell Cultures

Dear Colleagues,

Among the challenges raised by the recent Industry 4.0 revolution, mathematical modelling plays a key role in supervisory control and data acquisition (SCADA) systems used in industrial processes. In the specific context of biopharmaceuticals, where Process Analytical Technologies (PAT) are nowadays recommended for manufacturing, bioprocess yield and repeatability improvements are conditioned by the availability of dynamic models.

Mammalian cell cultures are the source of most biopharmaceutical therapeutics (monoclonal antibodies (MAbs), vaccines, glycoproteins, viral vectors, etc.), and the application of mechanistic and data-driven model-based software solutions has proved to significantly improve process productivity. However, some problematics remain, related to the inherent uncertainty of biosystems. Optimization methods may therefore be model-based—with some robust tolerance to model uncertainties—or model-free, using a limited a priori knowledge of process operation and without considering a full dynamic system.

This Special Issue focuses on original concepts in PAT and process monitoring, ranging from the application of instrumentation based on hardware and software sensors to the use of data-driven or model-based approaches. The submitted papers should present numerical and experimental applications for mammalian/human cell culture processes.

Dr. Laurent Dewasme
Dr. Véronique Chotteau
Prof. Dr. Alain Vande Wouwer
Guest Editors

Manuscript Submission Information

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