Advances in Bone Regeneration with Multipotential Stromal Cells and Bioactive Materials
A special issue of Bioengineering (ISSN 2306-5354).
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 1516
Special Issue Editors
Interests: mesenchymal stem cells/multipotential stromal cells (MSCs); bone regeneration; cartilage regeneration; osteoarthritis; regenerative medicine; regenerative orthopedics; MSC senescence
Special Issues, Collections and Topics in MDPI journals
Interests: cellular biology; mesenchymal stem cells; bone marrow microenvironment; cancer immunology
Special Issues, Collections and Topics in MDPI journals
Interests: mesenchymal stem cells/multipotential stromal cells (MSCs); MSC trophic and immunomodulatory actions; MSC functionalization ex vivo; inflammation and fibrosis reversal; synovitis; osteoarthritis; regenerative sports medicine; regenerative orthopaedics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The regeneration of large bone defects and fractures at risk of non-union is a serious clinical problem. Bone biological augmentation with autologous multipotential stromal/mesenchymal stem cells (MSCs) is deemed beneficial. However, clinical approaches vary considerably in terms of MSC tissue source, MSC isolation, the degree of MSC culture-expansion and priming ex vivo, and the use of biomaterial scaffolds. The aim of this Special Issue is to present a state-of-the-art update on the use of MSCs for bone regeneration. We welcome original research articles, comprehensive reviews, methods, mini-reviews, and perspectives including (but not limited to) the following topics:
- the benefits and limitations of using minimally manipulated autologous MSC isolates versus culture-expanded MSCs for bone repair;
- phenotype-based MSC isolation and/or priming, including the use of growth factors from autologous platelet concentrates;
- MSC and biomaterial functionalization, including gene-activated matrices;
- engineering of MSCs and immune cells for bone regeneration;
- personalized implants and therapies for patients with co-morbidities, including metabolic bone diseases;
- novel approaches to in vitro analysis of MSC–scaffold interactions in three-dimensional (3D) conditions;
- sensors and novel live imaging techniques for the assessment of bone regeneration in weight-bearing and non-weight-bearing bones
Prof. Dr. Elena A. Jones
Dr. Jehan J. El-Jawhari
Dr. Dimitrios Kouroupis
Guest Editors
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Keywords
- multipotential stromal/mesenchymal stem cells (MSCs)
- bone regeneration
- cell engineering
- activated matrices
- sensors and imaging
- scaffolds and biomaterials
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