Advances in Bone Regeneration with Multipotential Stromal Cells and Bioactive Materials

A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 1583

Special Issue Editors


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Guest Editor
Leeds Institute of Molecular Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK
Interests: mesenchymal stem cells/multipotential stromal cells (MSCs); bone regeneration; cartilage regeneration; osteoarthritis; regenerative medicine; regenerative orthopedics; MSC senescence
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Guest Editor
Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK
Interests: cellular biology; mesenchymal stem cells; bone marrow microenvironment; cancer immunology
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Guest Editor
Department of Orthopaedics, Division of Sports Medicine, Diabetes Research Institute, Cell Transplant Center, University of Miami, Miller School of Medicine, 1450NW 10th Ave, Room 3012, Miami, FL 33136, USA
Interests: mesenchymal stem cells/multipotential stromal cells (MSCs); MSC trophic and immunomodulatory actions; MSC functionalization ex vivo; inflammation and fibrosis reversal; synovitis; osteoarthritis; regenerative sports medicine; regenerative orthopaedics
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Special Issue Information

Dear Colleagues,

The regeneration of large bone defects and fractures at risk of non-union is a serious clinical problem. Bone biological augmentation with autologous multipotential stromal/mesenchymal stem cells (MSCs) is deemed beneficial. However, clinical approaches vary considerably in terms of MSC tissue source, MSC isolation, the degree of MSC culture-expansion and priming ex vivo, and the use of biomaterial scaffolds. The aim of this Special Issue is to present a state-of-the-art update on the use of MSCs for bone regeneration. We welcome original research articles, comprehensive reviews, methods, mini-reviews, and perspectives including (but not limited to) the following topics:

  • the benefits and limitations of using minimally manipulated autologous MSC isolates versus culture-expanded MSCs for bone repair;
  • phenotype-based MSC isolation and/or priming, including the use of growth factors from autologous platelet concentrates;
  • MSC and biomaterial functionalization, including gene-activated matrices;
  • engineering of MSCs and immune cells for bone regeneration;
  • personalized implants and therapies for patients with co-morbidities, including metabolic bone diseases;
  • novel approaches to in vitro analysis of MSC–scaffold interactions in three-dimensional (3D) conditions;
  • sensors and novel live imaging techniques for the assessment of bone regeneration in weight-bearing and non-weight-bearing bones

Prof. Dr. Elena A. Jones
Dr. Jehan J. El-Jawhari
Dr. Dimitrios Kouroupis
Guest Editors

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Keywords

  • multipotential stromal/mesenchymal stem cells (MSCs)
  • bone regeneration
  • cell engineering
  • activated matrices
  • sensors and imaging
  • scaffolds and biomaterials

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Published Papers

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