Application of Bioengineering to Clinical Orthodontics—2nd Edition

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 815

Special Issue Editors

Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong SAR, China
Interests: digital orthodontics; laser therapy in orthodontics; periodontal tissue regeneration

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Guest Editor
Division of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China
Interests: orthodontic tooth movement; bone biology; periodontal tissue remodeling
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Special Issue Information

Dear Colleagues,

Orthodontic treatment is where bioengineering meets artistry—a field in which precision and creativity combine to create harmonious teeth alignment and craniofacial structure. At its core, this discipline focuses on the relationship between tooth movement and craniofacial development, harnessing the body's natural processes to achieve both functional and aesthetic outcomes. Orthodontics rests on three pillars: biology, biomechanics, and biochemistry. These elements work together to transform applied forces into cellular responses, bone remodeling, and tissue adaptation. Success in the field requires a deep understanding of how tissues respond to forces, particularly in the remodeling of periodontal ligaments and alveolar bone. Through the careful application of biomechanical principles, orthodontists guide precise tooth movement, while biochemical processes direct cell activity and molecular signals that regulate the formation and breakdown of bone. This comprehensive knowledge enables orthodontists to design treatments that not only correct misaligned teeth but also ensure lasting stability and health—making orthodontics a true fusion of science and art.

This Special Issue, entitled “Application of Bioengineering to Clinical Orthodontics—2nd Edition”, aims to provide researchers, clinicians, and thought leaders with a platform to share their insights, discoveries, and breakthroughs in this field. We welcome submissions that delve into the biological mechanisms of tooth movement, the biomechanical principles guiding orthodontic force systems, the biochemical pathways driving craniofacial regeneration, and computer-aided diagnosis and treatment plans in craniofacial fields. The scope of this Special Issue includes, but is not limited to, novel biomaterials for orthodontic applications, tissue engineering approaches for bone remodeling, molecular insights into orthodontic tooth movement, AI-powered diagnosis in orthodontics, and the integration of digital technologies in treatment planning and execution. By fostering a collaborative platform for interdisciplinary research, this Special Issue seeks to advance our understanding of orthodontics as a transformative science and art, ultimately improving patient outcomes and shaping the future of craniofacial health. We welcome original research articles, reviews, and clinical studies that contribute to this exciting and evolving field. Join us in pushing the boundaries of orthodontic science and bioengineering.

Dr. Zhiyi Shan
Prof. Dr. Yanqi Yang
Guest Editors

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Keywords

  • biomechanics
  • biomaterials
  • tissue engineering
  • orthodontics
  • craniofacial regeneration
  • computer-aided diagnosis
  • AI used in craniofacial fields

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33 pages, 1347 KiB  
Review
Unleashing the Potential of Tannic Acid in Dentistry: A Scoping Review of Applications
by Xiaoqian Ding, Guanning Zhang, Cynthia Kar Yung Yiu, Xin Li and Zhiyi Shan
Bioengineering 2025, 12(5), 438; https://doi.org/10.3390/bioengineering12050438 - 22 Apr 2025
Viewed by 427
Abstract
(1) Background: Tannic acid (TA), a water-soluble polyphenol extensively found in numerous plant species, possesses antimicrobial, anti-inflammatory, antioxidant, and adhesive properties. This scoping review aims to synthesize existing knowledge on TA applications and unveil its potential uses in dentistry. (2) Methods: A comprehensive [...] Read more.
(1) Background: Tannic acid (TA), a water-soluble polyphenol extensively found in numerous plant species, possesses antimicrobial, anti-inflammatory, antioxidant, and adhesive properties. This scoping review aims to synthesize existing knowledge on TA applications and unveil its potential uses in dentistry. (2) Methods: A comprehensive search across six electronic databases (PubMed, Cochrane, Embase, Scopus, Web of Science, and Opengrey) was conducted in October 2024. Two reviewers performed the screening and risk of bias analysis independently following the PRISMA-ScR guidelines. The findings are presented in a narrative summary. (3) Results: Five hundred and twelve records were identified from the electronic databases. After removing duplicates and applying eligibility criteria, ninety-six studies were ultimately included in this review. Results indicate that TA has been employed in managing dentin hypersensitivity, dental caries, periodontal and mucosal diseases, as well as dentition defects with prostheses. Furthermore, TA displays potential in enhancing the performance of bonding adhesives, root canal irrigants, and root canal filling materials. However, it is noteworthy that the included studies exhibit varied experimental settings, inconsistent outcome measures, a lack of extensive clinical research, and insufficient observation periods. (4) Conclusions: TA is a promising biomaterial with applications to various dental fields, such as endodontics, periodontology, prosthodontics, and dental public health. Its antimicrobial, anti-inflammatory, antioxidant, and adhesive properties warrant future exploration to unleash these potentials and provide robust scientific evidence that guides clinical practice and advances oral healthcare. Full article
(This article belongs to the Special Issue Application of Bioengineering to Clinical Orthodontics—2nd Edition)
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