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4-Hydroxynonenal in Redox Homeostasis of Gastrointestinal Mucosa: Implications for the Stomach in Health and Diseases

1
Department of Internal Medicine #1, Danylo Halystkyi Lviv National Medical University, 79010 Lviv, Ukraine
2
Laboratory for Oxidative Stress (LabOS), Institute “Rudjer Boskovic”, HR-10000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
Antioxidants 2018, 7(9), 118; https://doi.org/10.3390/antiox7090118
Received: 26 July 2018 / Revised: 22 August 2018 / Accepted: 30 August 2018 / Published: 3 September 2018
(This article belongs to the Special Issue Antioxidants and Second Messengers of Free Radicals)
Maintenance of integrity and function of the gastric mucosa (GM) requires a high regeneration rate of epithelial cells during the whole life span. The health of the gastric epithelium highly depends on redox homeostasis, antioxidant defense, and activity of detoxifying systems within the cells, as well as robustness of blood supply. Bioactive products of lipid peroxidation, in particular, second messengers of free radicals, the bellwether of which is 4-hydroxynonenal (HNE), are important mediators in physiological adaptive reactions and signaling, but they are also thought to be implicated in the pathogenesis of numerous gastric diseases. Molecular mechanisms and consequences of increased production of HNE, and its protein adducts, in response to stressors during acute and chronic gastric injury, are well studied. However, several important issues related to the role of HNE in gastric carcinogenesis, tumor growth and progression, the condition of GM after eradication of Helicobacter pylori, or the relevance of antioxidants for HNE-related redox homeostasis in GM, still need more studies and new comprehensive approaches. In this regard, preclinical studies and clinical intervention trials are required, which should also include the use of state-of-the-art analytical techniques, such as HNE determination by immunohistochemistry and enzyme-linked immunosorbent assay (ELISA), as well as modern mass-spectroscopy methods. View Full-Text
Keywords: 4-hydroxynonenal; lipid peroxidation; redox balance; oxidative stress; stomach; peptic ulcer; gastritis; Helicobacter pylori; gastric cancer; non-steroid anti-inflammatory drugs-induced gastropathy 4-hydroxynonenal; lipid peroxidation; redox balance; oxidative stress; stomach; peptic ulcer; gastritis; Helicobacter pylori; gastric cancer; non-steroid anti-inflammatory drugs-induced gastropathy
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Cherkas, A.; Zarkovic, N. 4-Hydroxynonenal in Redox Homeostasis of Gastrointestinal Mucosa: Implications for the Stomach in Health and Diseases. Antioxidants 2018, 7, 118.

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