Oxidative Stress and Inflammatory Mechanisms in Vascular Disorders

Dear colleagues,

Cardiovascular diseases are the leading cause of death worldwide and involve several pathologies such as disorders of the coronary and peripheral arteries as well as cerebrovascular diseases. In addition, chronic inflammatory disorders have been identified as cardiovascular risks, and recent research has revealed the contribution of various inflammatory cells to vascular oxidative stress.

Inflammation is one of the key intermediate pathways involved in developing cardiovascular disorders, including atherosclerotic plaque development and rupture, aortic aneurysm formation, angiogenesis, and ischemia/reperfusion damage. Inflammation is a protective response of an organism to injury to localize, eliminate, and remove harmful stimuli and recover damaged tissues. The inflammatory response becomes pathogenic when it occurs at an inappropriate site or is excessive in extent or duration. Reactive oxygen species (ROS) are involved in the initiation, progression, and resolution of the inflammatory response in vascular disease. The activation of immune cells and recruitment to vascular tissues by cardiovascular risk factors lead to the activation of vascular ROS sources, which contribute to vascular dysfunction and the progression of the disease. Oxidative stress is defined by an imbalance between the production of ROS and the capacity of the antioxidant system to counteract the deleterious effects of oxidants. At physiological concentrations, ROS act as important mediators involved in regulating cell proliferation and differentiation, cell adhesion, migration, wound healing, angiogenesis, etc. In contrast, overproduction of ROS may result in cell and tissue injury and contribute to the development and progression of the inflammatory state underlying vascular diseases.

We invite you to submit your latest research findings or a review article to this Special Issue, which will bring together current research concerning oxidative stress and inflammatory mechanisms in vascular disorders.

Dr. Mercedes Camacho Pérez de Madrid
Dr. Josep Julve
Guest Editors

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