Implication of Oxidative Stress in Promoting Cell Senescence and Associated Pathologies

Dear Colleagues,

It is well known that exposure of several cell types to oxidative stress and reactive oxygen species (ROS) causes a wide range of effects, depending on the intensity and duration of exposure. These effects range from modification of signal transduction pathways and gene expression to an increased rate of cell proliferation, temporary or permanent inhibition of cell proliferation, and finally cell death either caused by apoptosis or necrosis. In the case of permanent inhibition of their proliferation, the cells remain alive but both their phenotype and functional state change dramatically, a condition usually called “cell senescence”.

The presence of increased numbers of senescent cells in tissues is associated with ageing, as well as with several age-associated pathologies such as tissue fibrosis, autoimmune diseases and cancer, among others. Additional knowledge about the molecular mechanisms that underline these interrelationships can lead to new therapeutic approaches for cell senescence-induced ageing and related pathological conditions.

For this Special Issue, we invite researchers to submit original works or review articles related to the implications of oxidative stress in the development of cell senescence, as well as age-related pathologies.

We look forward to receiving your contributions.

Prof. Dr. Dimitrios Galaris
Dr. Alexandra Barbouti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.