Special Issue "Nanomaterial Oxidative Stress"
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: closed (28 February 2017).
Interests: redox homeostasis; nanomaterial interactions with biological systems; oxidative stress; measurement issues
Nanomaterials (NMs) are defined as having components of at least one dimension between 1 nm and 100 nm (ISO/TS 80004-1), and include both manufactured and naturally occurring substances. Along with their unique properties, it was acknowledged early on that NMs could also have elevated toxicity. Redox properties of nanomaterials are intimately related to their toxic effects, and the induction of oxidative stress and subsequent inflammation is currently the main mechanistic paradigm of nanotoxicity. NMs could induce oxidative stress via a number of pathways. For example, generation of reactive oxygen species could result from the formation of electron hole pairs by photoactivation of some semiconductor nano-materials. In addition, dissolution of NMs releasing metal ions and the presence of transition metals such as Fe, Ni, Cu, Co, and Cr on the nanomaterial surface can generate hydroxyl radicals via the Fenton reaction. Finally, due to their uptake by cells, even inert NMs could give rise to ROS production by perturbing the mitochondria function and intracellular redox equilibria.
On the other hand, there is evidence that some nanomaterials have pronounced antioxidant properties. This Special Issue will highlight the complexity of NM-induced oxidative stress in biological systems, as well efforts to detect, measure, and alleviate its damaging consequences.
Dr. Vytas Reipa
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- oxidative stress
- reactive oxygen species
- redox homeostasis
- fenton reaction