Nanoantioxidants Volume II

Dear Colleagues,

Natural and engineered nanomaterials represent one of the most promising frontiers in the field of antioxidants. Natural-based biocompatible nanomaterials such as metal oxides, melanins, and lignin nanoparticles have demonstrated the possibility to act as radical scavengers with low toxicity. The possibility to easily functionalize the surface of nano-objects opens interesting applications such as modulation of the solubility and targeting.

The mechanisms of action that have been uncovered so far are the quenching of free radicals, and SOD – CAT – GPx enzyme-like behavior. The activity can be either intrinsic (such as in CeO₂ nanoparticles) or due to the covalent binding of small-molecule antioxidants to the surface. Nanomaterials can also reduce lipid peroxidation by reducing photoinitiation by absorbing UV-vis radiation. Another important field that is experiencing exponential growth is the use of nanocarriers (lipid particles, nanocapsules, nanotubes, etc.) to improve small-molecule antioxidant solubility and sustained release.

This Special Issue aims to collect recent developments in the field of the radical chemistry of nano-antioxidants, with a special focus on this non-exhaustive list of topics:

1) Preparation of novel nanomaterials having antioxidant activity;
2) Studies of the interaction of nanomaterials with free radicals, and ROS in general, with a special focus on alkylperoxyl radicals that propagate the lipid peroxidation;
3) Nanocarriers or nanocapsules for targeted transport and controlled release of antioxidants;
4) Biomimetic methods for measuring the efficacy of nanoantioxidants.

Dr. Riccardo Amorati
Guest Editor

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