Iron, Oxidative Stress, Skin Ageing and Disorders

Dear Colleagues,

Skin is constantly exposed to environmental oxidising agents, notably ultraviolet light, and is therefore the target of cumulative oxidative damage leading to photoageing and pathologies. Labile iron (LI) is potentially toxic to cells, as in the presence of reactive oxygen species (ROS) it can catalyse the formation of highly reactive oxygen-derived free radicals via Fenton chemistry, leading to oxidative stress and damage. Intracellular iron and redox homeostasis are tightly regulated to minimise LI and ROS levels, but during the process of ageing or under conditions of oxidative stress and pathologies, these regulations are severely compromised. The excess presence of LI and ROS has been observed in skin disorders such as psoriasis, venous ulceration, atopic eczema, vitiligo, and cancer. High levels of LI accumulation have also been recognised as a hallmark of ageing in the skin, promoting increased susceptibility to sunlight-mediated oxidative damage. This Special issue aims to (i) provide insights into novel mechanisms underlying iron- and ROS-mediated skin ageing/photoageing and disorders including wound healing; and (ii) critically review the recent trends in the use of natural, synthetic and/or bio-inspired antioxidants and iron chelators as medicaments for the topical therapy of skin disorders as well as anti-ageing/anti-photoageing ingredients for skin care and sunscreen formulations.

Prof. Dr. Charareh Pourzand
Prof. Dr. Julia Li Zhong
Prof. Dr. Mingxing Lei
Prof. Dr. XingHua Gao
Guest Editors

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