Iron Metabolism, Redox Balance and Neurological Diseases

Dear Colleagues,

The misregulation of brain iron homeostasis can lead to severe pathological changes in the neurological system. Iron deficiency slows the development of the neural system and causes mental and emotional disorders, while iron overload is closely related to neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and cerebral ischemia. Free iron can elicit the generation of reactive oxygen species (ROS) due to its ability to catalyze the Fenton reaction, which contributes significantly to the pathophysiological mechanisms of neurological diseases. On the other hand, some free radicals also play an important role in the normal function of cells as signaling molecules. Iron misregulation and redox imbalance are the keys to the occurrence and development of many neurological diseases. Therefore, iron metabolism and redox regulation as targets have become or will become a great potential solution for the treatment of neurological diseases. This Special Issue aims to collect the latest research findings and review articles with great advances on the mechanisms or treatments of neurological diseases related to iron misregulation/redox imbalance, and to stimulate new thinking in the field of iron metabolism, redox balance and neurological diseases.

Prof. Dr. Yan-Zhong Chang
Guest Editor

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