Special Issue "Flavonoids: Immune-Regulation and Health"

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: closed (30 October 2018)

Special Issue Editors

Guest Editor
Prof. Dr. Andrea I. Doseff

Department of Physiology and Department of Pharmacology and Toxicology, Department Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
Website | E-Mail
Interests: immune-regulation; innate immunity; apoptosis; cancer cell resistance; inflammatory diseases; functional foods; flavonoid gene regulatory networks; foods for health; flavonoid target identification
Guest Editor
Dr. Jennifer Ahn-Jarvis

Department Food for Health, Quadram Institute Bioscience, Norwich Research Park, NR4 7UA, UK
E-Mail
Interests: functional foods; foods for health

Special Issue Information

Dear Colleagues,

Dietary flavonoids are emerging as promising candidates for the prevention and treatment of inflammatory diseases. Thus, there is increasing interest in understanding the mechanisms of action of dietary flavonoids with potential health benefits. Flavonoids anti-oxidant activities and function in cellular redox signalling support their accepted role as metabolic regulators. Emerging new roles as immune-regulators present exciting opportunities to control inflammatory diseases. Recent findings revealed unexpected additional mechanisms underlying the health beneficial effects of flavonoids. Flavonoids associate with proteins, altering gene regulatory networks, RNA metabolism and protein signalling. A better understanding of the direct targets of flavonoids, the binding affinities and physiological effects in preclinical models of disease are needed to move the field forward. The development of functional foods and new delivery systems opens new opportunities for the clinical utilization of flavonoids for the prevention and treatment of inflammatory diseases.

This Special Issue welcomes original research papers or reviews that contribute to our understanding on the molecular mechanisms of dietary flavonoids and their role in the prevention and treatment of inflammatory diseases. Special interests include: Mechanistic insights into the function of flavonoids as anti-oxidants; regulators of signal transduction pathways; flavonoids and the effects on gene regulation; functional foods and plants for health; mechanistic roles of flavonoids in the modulation of the immune system; clinical trials of dietary flavonoids for disease prevention and treatment; and flavonoids and metabolic function.

Prof. Dr. Andrea I. Doseff
Dr. Jennifer Ahn-Jarvis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Immune-regulation
  • Macrophages
  • Apoptosis
  • Cancer
  • Inflammatory diseases
  • Foods for health
  • Functional foods
  • Protein signaling
  • Gene regulatory networks
  • Metabolic function

Published Papers (2 papers)

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Review

Open AccessReview
Flavonoids: New Frontier for Immuno-Regulation and Breast Cancer Control
Antioxidants 2019, 8(4), 103; https://doi.org/10.3390/antiox8040103
Received: 25 February 2019 / Revised: 1 April 2019 / Accepted: 5 April 2019 / Published: 16 April 2019
Cited by 1 | PDF Full-text (611 KB) | HTML Full-text | XML Full-text
Abstract
Breast cancer (BC) remains the second most common cause of cancer-related deaths in women in the US, despite advances in detection and treatment. In addition, breast cancer survivors often struggle with long-term treatment related comorbidities. Identifying novel therapies that are effective while minimizing [...] Read more.
Breast cancer (BC) remains the second most common cause of cancer-related deaths in women in the US, despite advances in detection and treatment. In addition, breast cancer survivors often struggle with long-term treatment related comorbidities. Identifying novel therapies that are effective while minimizing toxicity is critical in curtailing this disease. Flavonoids, a subclass of plant polyphenols, are emerging as promising treatment options for the prevention and treatment of breast cancer. Recent evidence suggests that in addition to anti-oxidant properties, flavonoids can directly interact with proteins, making them ideal small molecules for the modulation of enzymes, transcription factors and cell surface receptors. Of particular interest is the ability of flavonoids to modulate the tumor associated macrophage function. However, clinical applications of flavonoids in cancer trials are limited. Epidemiological and smaller clinical studies have been largely hypothesis generating. Future research should aim at addressing known challenges with a broader use of preclinical models and investigating enhanced dose-delivery systems that can overcome limited bioavailability of dietary flavonoids. In this review, we discuss the structure-functional impact of flavonoids and their action on breast tumor cells and the tumor microenvironment, with an emphasis on their clinical role in the prevention and treatment of breast cancer. Full article
(This article belongs to the Special Issue Flavonoids: Immune-Regulation and Health)
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Open AccessReview
Flavonoids and Colorectal Cancer Prevention
Antioxidants 2018, 7(12), 187; https://doi.org/10.3390/antiox7120187
Received: 26 September 2018 / Revised: 3 November 2018 / Accepted: 4 December 2018 / Published: 10 December 2018
Cited by 1 | PDF Full-text (711 KB) | HTML Full-text | XML Full-text
Abstract
Colorectal cancer (CRC) is the third most common cancer, but despite advances in treatment, it remains the second most common cause of cancer-related mortality. Prevention may, therefore, be a key strategy in reducing colorectal cancer deaths. Given reports of an inverse association between [...] Read more.
Colorectal cancer (CRC) is the third most common cancer, but despite advances in treatment, it remains the second most common cause of cancer-related mortality. Prevention may, therefore, be a key strategy in reducing colorectal cancer deaths. Given reports of an inverse association between fruit and vegetable consumption with colorectal cancer risk, there has been significant interest in understanding the metabolism and bioactivity of flavonoids, which are highly abundant in fruits and vegetables and account for their pigmentation. In this review, we discuss host and microbiota-mediated metabolism of flavonoids and the potential mechanisms by which flavonoids can exert protective effects against colon tumorigenesis, including regulation of signaling pathways involved in apoptosis, cellular proliferation, and inflammation and modulation of the gut microbiome. Full article
(This article belongs to the Special Issue Flavonoids: Immune-Regulation and Health)
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