Special Issue "Flavonoids: Immune-Regulation and Health"

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: closed (30 October 2018)

Special Issue Editors

Guest Editor
Prof. Dr. Andrea I. Doseff

Department of Physiology and Department of Pharmacology and Toxicology, Department Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
Website | E-Mail
Interests: immune-regulation; innate immunity; apoptosis; cancer cell resistance; inflammatory diseases; functional foods; flavonoid gene regulatory networks; foods for health; flavonoid target identification
Guest Editor
Dr. Jennifer Ahn-Jarvis

Department Food for Health, Quadram Institute Bioscience, Norwich Research Park, NR4 7UA, UK
Interests: functional foods; foods for health

Special Issue Information

Dear Colleagues,

Dietary flavonoids are emerging as promising candidates for the prevention and treatment of inflammatory diseases. Thus, there is increasing interest in understanding the mechanisms of action of dietary flavonoids with potential health benefits. Flavonoids anti-oxidant activities and function in cellular redox signalling support their accepted role as metabolic regulators. Emerging new roles as immune-regulators present exciting opportunities to control inflammatory diseases. Recent findings revealed unexpected additional mechanisms underlying the health beneficial effects of flavonoids. Flavonoids associate with proteins, altering gene regulatory networks, RNA metabolism and protein signalling. A better understanding of the direct targets of flavonoids, the binding affinities and physiological effects in preclinical models of disease are needed to move the field forward. The development of functional foods and new delivery systems opens new opportunities for the clinical utilization of flavonoids for the prevention and treatment of inflammatory diseases.

This Special Issue welcomes original research papers or reviews that contribute to our understanding on the molecular mechanisms of dietary flavonoids and their role in the prevention and treatment of inflammatory diseases. Special interests include: Mechanistic insights into the function of flavonoids as anti-oxidants; regulators of signal transduction pathways; flavonoids and the effects on gene regulation; functional foods and plants for health; mechanistic roles of flavonoids in the modulation of the immune system; clinical trials of dietary flavonoids for disease prevention and treatment; and flavonoids and metabolic function.

Prof. Dr. Andrea I. Doseff
Dr. Jennifer Ahn-Jarvis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Immune-regulation
  • Macrophages
  • Apoptosis
  • Cancer
  • Inflammatory diseases
  • Foods for health
  • Functional foods
  • Protein signaling
  • Gene regulatory networks
  • Metabolic function

Published Papers

There is no accepted submissions to this special issue at this moment.
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