Redox Effects of Molecular Hydrogen and Its Potential for Preventive and Therapeutic Applications

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "ROS, RNS and RSS".

Deadline for manuscript submissions: 10 March 2024 | Viewed by 11234

Special Issue Editors

Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea
Interests: molecular hydrogen; inflammation; oxidative stress; antioxidant; alkaline ionized water
Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea
Interests: functional water; hydrogen; hypochlorous acid; life; energy; global health; agriculture
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Special Issue Information

Dear Colleagues,

With the development of science and technology, life extension and the prevention and treatment of accompanying diseases have become topics of international concern in the healthcare field, and molecular hydrogen has been identified as a safe and effective material to solve these health-related problems.

Molecular hydrogen is proposed as a medicinal gas, which has antioxidant, anti-apoptotic, and signal-regulating properties that protect cells and tissues by selectively neutralizing hydroxyl radicals. However, different diseases and associated factors have not yet been fully elucidated.

Our goal here is to determine how to improve the ability to use molecular hydrogen in oxidative stress using various enzymes in cells, animals, or humans. This issue could help with the development of new therapies and biomarkers with underlying molecular hydrogen mechanisms.

Molecular hydrogen serves as a scavenger to modify ROS and maintain metabolic oxidation–reduction reaction in various biomedical areas. It can also neutralize and convert highly active oxidants such as hydroxyl radical and peroxynitrite into water. Thus, the redox effect of molecular hydrogen is crucial to find preventive and therapeutic applications.

Recently, molecular hydrogen has begun to be applied to various diseases based on the academic mechanism of regulating the immune system and removing free radicals. It is expected to contribute to the use of molecular hydrogen in health promotion through the report of excellent research results related to molecular hydrogen.

Dr. Cheol-Su Kim
Prof. Dr. Kyu-Jae Lee
Guest Editors

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Keywords

  • molecular hydrogen
  • oxidative stress
  • antioxidant
  • anti-inflammation
  • anti-apoptosis
  • signal transduction
  • ROS regulation
  • hydrogen therapy
  • hydrogen gas
  • hydrogen water
  • alkaline ionized water
  • immune-redox
  • inflammatory disease
  • preventive treatment

Published Papers (3 papers)

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Research

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14 pages, 2315 KiB  
Article
Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial
Antioxidants 2023, 12(6), 1241; https://doi.org/10.3390/antiox12061241 - 08 Jun 2023
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Abstract
Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including Alzheimer’s disease (AD). Herein, we investigated the effects of 4 weeks of H2 gas [...] Read more.
Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including Alzheimer’s disease (AD). Herein, we investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages. Fifty-four participants, including those who dropped out (5%), were screened and enrolled. The selected participants were treated as a single group without randomization. We evaluated the association between total and differential white blood cell (WBC) counts and AD risk at individual levels after 4 weeks of H2 gas inhalation treatment. The total and differential WBC counts were not adversely affected after H2 gas inhalation, indicating that it was safe and well tolerated. Investigation of oxidative stress markers such as reactive oxygen species and nitric oxide showed that their levels decreased post-treatment. Furthermore, evaluation of dementia-related biomarkers, such as beta-site APP cleaving enzyme 1 (BACE-1), amyloid beta (Aβ), brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor A (VEGF-A), T-tau, monocyte chemotactic protein-1 (MCP-1), and inflammatory cytokines (interleukin-6), showed that their cognitive condition significantly improved after treatment, in most cases. Collectively, our results indicate that H2 gas inhalation may be a good candidate for improving AD with cognitive dysfunction in community-dwelling adults of different ages. Full article
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12 pages, 2303 KiB  
Article
Molecular Hydrogen Prevents Osteoclast Activation in a Glucocorticoid-Induced Osteoporosis Zebrafish Scale Model
Antioxidants 2023, 12(2), 345; https://doi.org/10.3390/antiox12020345 - 01 Feb 2023
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Abstract
Antioxidants represent a powerful tool for many human diseases and, in particular, molecular hydrogen has unique characteristics that make it a very promising therapeutic agent against osteoporosis. Zebrafish scales offer an innovative model in which new therapeutic approaches against secondary osteoporosis are tested. [...] Read more.
Antioxidants represent a powerful tool for many human diseases and, in particular, molecular hydrogen has unique characteristics that make it a very promising therapeutic agent against osteoporosis. Zebrafish scales offer an innovative model in which new therapeutic approaches against secondary osteoporosis are tested. Scale bone loss obtained by prednisolone (PN) treatment is characterized by increased osteoclast activity and decreased osteoblast activity highlighted with bone enzymatic assays. We used this read-out system to test the therapeutic effects of hydrogen-rich water (HRW), an innovative antioxidant approach. HRW prevented osteoclast activation and bone loss in PN-treated fish scales, as verified by both biochemical and histochemical tartrate-resistant alkaline phosphatase assays. On the other hand, HRW treatment did not prevent PN-dependent osteoblast suppression, as measured by alkaline phosphatase activity. Moreover, HRW treatment did not facilitate the reparation of resorption lacunae induced in scales by PN. Our study highlighted a specific effect of HRW on adult osteoclast activity but not in osteoblasts, introducing an intriguing new antioxidant preventive approach against osteoporosis. Full article
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19 pages, 1094 KiB  
Review
Redox-Mechanisms of Molecular Hydrogen Promote Healthful Longevity
by , , , and
Antioxidants 2023, 12(5), 988; https://doi.org/10.3390/antiox12050988 - 24 Apr 2023
Cited by 2 | Viewed by 5622
Abstract
Age-related diseases represent the largest threat to public health. Aging is a degenerative, systemic, multifactorial and progressive process, coupled with progressive loss of function and eventually leading to high mortality rates. Excessive levels of both pro- and anti-oxidant species qualify as oxidative stress [...] Read more.
Age-related diseases represent the largest threat to public health. Aging is a degenerative, systemic, multifactorial and progressive process, coupled with progressive loss of function and eventually leading to high mortality rates. Excessive levels of both pro- and anti-oxidant species qualify as oxidative stress (OS) and result in damage to molecules and cells. OS plays a crucial role in the development of age-related diseases. In fact, damage due to oxidation depends strongly on the inherited or acquired defects of the redox-mediated enzymes. Molecular hydrogen (H2) has recently been reported to function as an anti-oxidant and anti-inflammatory agent for the treatment of several oxidative stress and aging-related diseases, including Alzheimer’s, Parkinson’s, cancer and osteoporosis. Additionally, H2 promotes healthy aging, increases the number of good germs in the intestine that produce more intestinal hydrogen and reduces oxidative stress through its anti-oxidant and anti-inflammatory activities. This review focuses on the therapeutic role of H2 in the treatment of neurological diseases. This review manuscript would be useful in knowing the role of H2 in the redox mechanisms for promoting healthful longevity. Full article
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