Melatonin Metabolism and Aging
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (15 June 2024) | Viewed by 4647
Special Issue Editor
Interests: pancreatic islet; insulin; glucagon; somatostatin; melatonin receptor; glucose transporter; natural killer cells; pancreatic ductal adenocarcinoma; fatty liver; glucose metabolism
Special Issue Information
Dear Colleagues,
Melatonin is an important hormone of the circadian system and is centrally synthesized in vertebrates' pineal gland during the night. Aside from that, local synthesis is also described in several tissues and cells (e.g., retina, gut, immune cells). In the pineal gland, tryptophan is converted to melatonin via various intermediate stages, whereby the arylalkylamine N-acetyltransferase represents the key enzyme. Melatonin is widely known as a pleiotropic and universal antioxidant molecule, which regulates many physiological functions, e.g., the sleep–wake cycle, redox homeostasis, lipid and glucose metabolism and it additionally plays a role in the immune system. The effects of melatonin are indirectly mediated via melatonin receptors, which are found in most mammalian tissues. Another possibility is the direct transmission through interaction with intracellular components. Enzymatic melatonin degradation mainly occurs in the liver, mediated by the major enzyme cytochrome P450. Additionally, melatonin can be metabolized by other enzymatic, non-enzymatic, or free radical interactive processes. Reduction in melatonin secretion, especially decreased melatonin plasma levels, is increasingly discussed in association with aging and age-related diseases.
This Special Issue should provide further insights and knowledge about molecular signaling and cellular mechanisms underlying melatonin function as well as components involved in mammalian cells' melatonin metabolism. In this context, the influence of aging or age-related diseases should be particularly considered.
Dr. Ivonne Bazwinsky-Wutschke
Guest Editor
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