Bridging Oxidative Stress and Aberrant Nutrient Metabolism in Metabolic Diseases

Dear Colleagues,

Both humans and animals are afflicted with a variety of metabolic diseases, representing medical and economic concerns to the global community. Organisms rely heavily on the tight coordination of redox reactions and nutrient metabolism to maintain cellular function and therefore aid in the prevention and resolution of disease and inflammation. However, during nutrient excess, reactive metabolites can overwhelm antioxidant defenses, inflammation can become protracted and nutrient metabolism can become altered, promoting metabolic health disorders (e.g., metabolic syndrome/stress, cardiometabolic disease). Indeed, growing evidence suggests that oxidative stress, dysregulated inflammation, and aberrant nutrient metabolism are major underlying components of metabolic disease pathophysiology. As each factor not only contributes to disease pathogenesis individually but also in concert with one another, it is important to understand the complex relationship between them to better understand metabolic health disorders.

In this Special Issue, we invite original articles and reviews that discuss the intimate role of oxidative stress, dysregulated inflammation, and aberrant nutrient metabolism in metabolic diseases of humans and animals.

We look forward to your contribution.

Dr. Ashley K. Putman
Dr. Emilio Mottillo
Guest Editors

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