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Antioxidants
Special Issues
Bridging Oxidative Stress and Aberrant Nutrient Metabolism in Metabolic Diseases
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Bridging Oxidative Stress and Aberrant Nutrient Metabolism in Metabolic Diseases

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 6728

Special Issue Editors

Dr. Ashley K. Putman

E-Mail Website
Guest Editor
1. Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, 784 Wilson Road, East Lansing, MI 48823, USA
2. Hypertension and Vascular Research Division, Henry Ford Hospital, 6135 Woodward Avenue, Detroit, MI 48202, USA
Interests: oxidative stress; lipid mediators
Dr. Emilio Mottillo

E-Mail Website
Guest Editor
1. Hypertension and Vascular Research Division, Henry Ford Hospital, 6135 Woodward Avenue, Detroit, MI 48202, USA
2. Department of Physiology, Wayne State University, 540 E Canfield St., Detroit, MI 48202, USA
Interests: lipid metabolism; adipose biology; fatty liver disease; obesity

Special Issue Information

Dear Colleagues,

Both humans and animals are afflicted with a variety of metabolic diseases, representing medical and economic concerns to the global community. Organisms rely heavily on the tight coordination of redox reactions and nutrient metabolism to maintain cellular function and therefore aid in the prevention and resolution of disease and inflammation. However, during nutrient excess, reactive metabolites can overwhelm antioxidant defenses, inflammation can become protracted and nutrient metabolism can become altered, promoting metabolic health disorders (e.g., metabolic syndrome/stress, cardiometabolic disease). Indeed, growing evidence suggests that oxidative stress, dysregulated inflammation, and aberrant nutrient metabolism are major underlying components of metabolic disease pathophysiology. As each factor not only contributes to disease pathogenesis individually but also in concert with one another, it is important to understand the complex relationship between them to better understand metabolic health disorders.

In this Special Issue, we invite original articles and reviews that discuss the intimate role of oxidative stress, dysregulated inflammation, and aberrant nutrient metabolism in metabolic diseases of humans and animals.

We look forward to your contribution.

Dr. Ashley K. Putman
Dr. Emilio Mottillo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic disease
  • cardiometabolic health
  • oxidative stress
  • nutrient metabolism
  • dysregulated inflammation

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Published Papers (2 papers)

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Research

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21 pages, 4345 KiB  
Article
The Influence of Caramel Carbon Quantum Dots and Caramel on Platelet Aggregation, Protein Glycation and Lipid Peroxidation
by Magdalena Kotańska, Konrad Wojtaszek, Monika Kubacka, Marek Bednarski, Noemi Nicosia and Marek Wojnicki
Antioxidants 2024, 13(1), 13; https://doi.org/10.3390/antiox13010013 - 20 Dec 2023
Cited by 3 | Viewed by 2200
Abstract
Caramel, defined as a coloring agent and as an antioxidant, is used in several kinds of food products and is consumed by many people in different amounts. In our research we showed that the caramelization of sucrose under special conditions leads to the [...] Read more.
Caramel, defined as a coloring agent and as an antioxidant, is used in several kinds of food products and is consumed by many people in different amounts. In our research we showed that the caramelization of sucrose under special conditions leads to the formation of carbon quantum dots (CQDs). So, it makes sense that humans also consume this type of CQDs, and it is theoretically possible for these particles to affect the body. Despite an increasing number of studies describing different types of CQDs, their biosafety is still not clearly understood. In our in vitro research, we examined the effects on platelet aggregation, protein glycation and lipid peroxidation of CQDs and caramel formed from a 20% sucrose solution. In vitro aggregation tests were conducted using freshly collected whole rat blood in a multiplate platelet function analyzer and measurer of electric impedance. The cytotoxic effect of the tested solutions on blood platelets was evaluated based on the release of lactate dehydrogenase. The formation of glycated bovine serum albumin was measured as fluorescence intensity and fructosamine level. The reducing power of the solutions was determined in adipose tissue, and their effect on lipid peroxidation in adipose tissue in vitro was also assessed. By measuring the intensity of hemolysis after incubation in solutions with red blood cell, we assessed their influence on the integration of the red blood cell membrane. All tests were performed in comparison with glucose and fructose and other frequently used sweeteners, such as erythritol and xylitol. Our study showed that caramel and CQDs formed from caramel may influence the glycation process and integrity of the red blood cell membrane, but unlike glucose and fructose, they decrease lipid peroxidation and may reduce Fe (III). Additionally, it is unlikely that they affect platelet aggregation. Compared to glucose and fructose, they may be safer for patients with metabolic disorders; however, further research is needed on the safety and biological activity of caramel and CQD. Full article
(This article belongs to the Special Issue Bridging Oxidative Stress and Aberrant Nutrient Metabolism in Metabolic Diseases)
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Review

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33 pages, 2315 KiB  
Review
The Intersection of Genetic Factors, Aberrant Nutrient Metabolism and Oxidative Stress in the Progression of Cardiometabolic Disease
by Andrew J. Butcko, Ashley K. Putman and Emilio P. Mottillo
Antioxidants 2024, 13(1), 87; https://doi.org/10.3390/antiox13010087 - 10 Jan 2024
Cited by 4 | Viewed by 3548
Abstract
Cardiometabolic disease (CMD), which encompasses metabolic-associated fatty liver disease (MAFLD), chronic kidney disease (CKD) and cardiovascular disease (CVD), has been increasing considerably in the past 50 years. CMD is a complex disease that can be influenced by genetics and environmental factors such as [...] Read more.
Cardiometabolic disease (CMD), which encompasses metabolic-associated fatty liver disease (MAFLD), chronic kidney disease (CKD) and cardiovascular disease (CVD), has been increasing considerably in the past 50 years. CMD is a complex disease that can be influenced by genetics and environmental factors such as diet. With the increased reliance on processed foods containing saturated fats, fructose and cholesterol, a mechanistic understanding of how these molecules cause metabolic disease is required. A major pathway by which excessive nutrients contribute to CMD is through oxidative stress. In this review, we discuss how oxidative stress can drive CMD and the role of aberrant nutrient metabolism and genetic risk factors and how they potentially interact to promote progression of MAFLD, CVD and CKD. This review will focus on genetic mutations that are known to alter nutrient metabolism. We discuss the major genetic risk factors for MAFLD, which include Patatin-like phospholipase domain-containing protein 3 (PNPLA3), Membrane Bound O-Acyltransferase Domain Containing 7 (MBOAT7) and Transmembrane 6 Superfamily Member 2 (TM6SF2). In addition, mutations that prevent nutrient uptake cause hypercholesterolemia that contributes to CVD. We also discuss the mechanisms by which MAFLD, CKD and CVD are mutually associated with one another. In addition, some of the genetic risk factors which are associated with MAFLD and CVD are also associated with CKD, while some genetic risk factors seem to dissociate one disease from the other. Through a better understanding of the causative effect of genetic mutations in CMD and how aberrant nutrient metabolism intersects with our genetics, novel therapies and precision approaches can be developed for treating CMD. Full article
(This article belongs to the Special Issue Bridging Oxidative Stress and Aberrant Nutrient Metabolism in Metabolic Diseases)
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