Oxidative Stress in Neurons

Dear Colleagues,

The brain is especially vulnerable to damage from reactive oxygen species (ROS), likely due to unique metabolic properties and the activities of the available antioxidant response pathways. Oxidative stress due to ROS contributes substantially to neuronal cell function and ultimately the development of neurological disorders; thus, the correct functioning of antioxidant defence systems is essential for cellular survival in the central nervous system and the maintenance of cognition. Oxidative stress is a hallmark of major neurodegenerative disorders, including amyotrophic lateral sclerosis, Parkinson’s and Alzheimer’s disease, as well as ageing. Importantly, oxidative stress markers are present in cell populations selectively targeted in neurodegeneration, and pathogenic mutations occur in proteins that feature prominently in antioxidant pathways. Oxidative stress is also an important feature of many other major neurological disorders including multiple sclerosis and epilepsy, and fundamental aspects of neurotransmission and neurodevelopment are also influenced by the damaging properties of ROS, but also their role as valuable signalling molecules.

This Special Issue of Antioxidants will focus on the role of oxidative stress and antioxidant pathways in neurons, with the aim of bringing together new data and commentaries on all aspects of neuronal cell function in relation to ROS, with relevance to specific disease states and defined neuronal populations in addition to the function and potential therapeutic manipulation of endogenous antioxidant mechanisms.

Dr. Peter L. Oliver
Prof. Dr. Bobby Thomas
Guest Editors

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