Oxidative stress and Applied Biology

Dear Colleagues,

The concept of oxidative stress was introduced into redox biology and medicine in 1985 by Sies. "Oxidative stress" is a phenomenon characterized by an imbalance between the production and the accumulation of oxidants (oxygen and nitrogen reactive species (ROS/RNS)) and the ability of the antioxidant system to remove these reactive products.

Much data in the literature indicate that oxidative stress plays a significant role in the pathogenesis of premature aging and in inflammatory and/or degenerative diseases. Oxidative stress is recognized as a possible cause or a contributing cause or effect in the development of the above-mentioned diseases. For this reason, for a long time, oxidative stress has been called "harmful". Recently, the importance of ROS as second messengers in the physiology of cells has been better understood. In fact, many fundamental cellular processes such as cell proliferation and differentiation, migration and cell adhesion are based on changes in the activity of many proteins involved in cell signaling, which act as redox-sensitive molecular switches.

This has led to an evolution of the initial concept of "oxidative stress" or damage of the cellular structure to include the subsequent stress response, including the modulation of cellular signaling pathways, homeostasis and redox adaptation to stress. This new concept has made it possible to exploit "oxidative stress" as a therapeutic approach to treat diseases such as cancer, resulting in a certain degree of clinical success. In this Special Issue, we invite researchers to provide original research articles and review articles that report results in the field of oxidative stress that are negative and/or positive for human health, taking different aspects of applied biology research (environmental and human biology and health sciences) into consideration, with particular attention to the role of ROS in the basic mechanisms involved in processes of expression, duplication, and transmission of genetic information, development, cell proliferation as well as differentiation and cellular interaction.

As Guest Editor, I invite you to contribute to the Special Issue on “Oxidative Stress and Applied Biology”. Original research reports and reviews will be published online in Antioxidants.

Prof. Antonia Patruno
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.