Cell Therapy and Redox Regulation in Diseases: Potential and Implications

Dear Colleagues,

In recent decades, diseases that affect different tissues, organs, or systems have found new treatment approaches derived from so-called cell therapies. After many years in which bone-marrow transplants were the only cell therapies available for treating leukemias, the use of so-called “stem cells” began to spread throughout the world. Studies were initially restricted to basic experimentation (cellular and molecular) and pre-clinical assays using embryonic stem cells, mesenchymal cells (such as those from adipose tissue), bone-marrow mononuclear cells, and more recently, induced pluripotent cells. With the proliferation of successful clinical trials, a new field has emerged from the use of these cells—one that exploits the extracellular vesicles they secrete. Tissue redox alterations being one of the central features of highly prevalent acute and chronic diseases, the antioxidant potential of stem or related cells and the vesicles secreted by them has opened a new perspective: cell therapies that prevent, attenuate, or cure redox anomalies. The main objective of this Special Issue of Antioxidants is to capture a broad spectrum of original studies and reviews that involve, at the same time, experimental models or treatments with cellular or acellular therapies in infectious and non-infectious diseases, acute or chronic diseases (including degenerative), and targeting mechanisms of repair for redox alterations.

Dr. Claudia Fernanda Fernanda Dick
Dr. Adalberto Vieyra
Guest Editors

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