Nanotechnology and Redox Health

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (22 March 2025) | Viewed by 800

Special Issue Editors


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Guest Editor
Post-Graduate Program in Pharmaceutical Sciences, Universidade Estadual de Maringa, Maringa 5790, Brazil
Interests: photoprotection; nanotechnology; oxidative stress; chemotherapy of trypanosomatids; inflammation
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmacology, University of São Paulo, Institute of Biomedical Sciences (USP-ICB), São Paulo, Brazil
Interests: cell signaling; nanotechnology; oxidative stress; photoprotection; wound healing
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Post-Graduate Program in Pharmaceutical Sciences, Universidade Estadual de Maringá, Maringá 87020-900, Paraná, Brazil
Interests: nanotechnology; oxidative stress; chemotherapy of trypanosomatids; photoprotection

Special Issue Information

Dear Colleagues,

Nanotechnology is an interdisciplinary field that deals with the manipulation, creation, and use of materials, devices, and systems at nanometric scales, in turn offering innovative solutions in various domains, including healthcare. Concurrently, redox health refers to the balance between oxidants and reductants within the body. Oxidative stress, resulting from an imbalance favoring reactive oxygen species (ROS) and reactive nitrogen species (RNS), contributes to the pathogenesis of various chronic diseases. Nanotechnology holds great potential in revolutionizing the treatment of chronic diseases, offering novel tools for early diagnosis, targeted therapy, and tissue regeneration. Research in this field is promising and could lead to significant advancements in public health. In this Special Issue, we aim to explore the intersection of nanotechnology and redox health management. We invite researchers to submit original research reports and reviews that address the potential of nanomedicine to prevent or treat chronic conditions associated with oxidative stress (e.g.,  cancer, cardiovascular disorders, neurodegenerative conditions, and metabolic syndromes). Specific areas of interest include the nanocarrier-based delivery of antioxidants, the use of nanomaterials for modulating redox signaling pathways involved in disease progression, and the use of redox-responsive nanomaterials for controlled drug release.

Prof. Dr. Sueli De Oliveira Silva Lautenschlager
Prof. Dr. Regina Gomes Daré
Dr. Danielle Lazarin Bidóia
Guest Editors

Manuscript Submission Information

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Keywords

  • nanotechnology
  • nanomedicine
  • oxidative stress
  • antioxidants
  • chronic diseases

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Published Papers (1 paper)

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Research

14 pages, 8033 KiB  
Article
GSH-Responsive Nano-Photosensitizer for Potentiating Photodynamic Therapy Through Multi-Pronged Synergistic Upregulation of Ferroptosis Sensitivity
by Yunong Ma, Kexin Xu, Jing Feng, Xi Zhao, Peilin Tian, Jiayang Luo, Luyao Xu, Jiaxing Song and Cuixia Lu
Antioxidants 2025, 14(4), 407; https://doi.org/10.3390/antiox14040407 - 28 Mar 2025
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Abstract
Impeded by the limited light penetration of photodynamic therapy (PDT) to tissues and the hypoxic environment of solid tumors, the clinical therapeutic efficacy and application are below expectations. In this study, a glutathione (GSH)-responsive nano-photosensitizer, based on the chlorquinaldol (CQD)-loaded iron-containing nanorod composed [...] Read more.
Impeded by the limited light penetration of photodynamic therapy (PDT) to tissues and the hypoxic environment of solid tumors, the clinical therapeutic efficacy and application are below expectations. In this study, a glutathione (GSH)-responsive nano-photosensitizer, based on the chlorquinaldol (CQD)-loaded iron-containing nanorod composed of meso-tetra (4-carboxyphenyl) porphyrin (TCPP), was prepared to serve as the laser-ignited ferroptosis sensitizer to improve the tumoricidal effect of PDT. In the tumor microenvironment (TME) with elevated GSH levels, therapeutic cargos and ferrous ions are released and are accompanied by the degradation of the nano-photosensitizer and GSH exhaustion. This not only increases liable iron pool (LIP) accumulation by the released ferrous ions but also decreases glutathione peroxidase 4 (GPX4) activity by GSH exhaustion. Simultaneously, GSH exhaustion disrupts intracellular redox homeostasis, heightening NIR light irradiation-triggered photosensitive oxidative stress. Moreover, the released CQD elevates the level of intracellular reactive oxygen species (ROS), enabling the nanorods to gain an oxygen radical generation ability and enhancing the photosensitive oxidative therapeutic efficacy. Strikingly, CQD exacerbates the downregulation of GPX4 expression to promote the accumulation of lipid peroxides. Therefore, we herald a new paradigm for synergistically potentiating PDT based on the “all-in-one” nano-photosensitizer through the multi-pronged upregulation of ferroptosis sensitivity. Full article
(This article belongs to the Special Issue Nanotechnology and Redox Health)
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