Influence of Gut Microbiota on Antioxidant Capacity of Foods—2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Extraction and Industrial Applications of Antioxidants".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 2293

Special Issue Editors


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Guest Editor
Department of Pharmacology and Pediatric medicine, School of Medicine, University of Malaga, 29013 Malaga, Spain
Interests: antioxidant capacity; polyphenols; gut microbiota; microbial metabolites; inflammation; coffee; melanoidins
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Guest Editor
1. Department of Nutrition and Food Science, Institute of Nutrition and Food Technology, Biomedical Research Centre, University of Granada, 18071 Granada, Spain
2. Instituto de Investigación Biosanitaria (ibs. GRANADA), Universidad de Granada, 18071 Granada, Spain
Interests: antioxidant capacity; personalized nutrition; gut microbiota; chemical browning; diet
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following the success of the previous Special Issue "Influence of Gut Microbiota on Antioxidant Capacity of Foods", we have decided to pursuit a second edition.

The antioxidant capacity of many different foods has been widely studied over the years, identifying highly antioxidant compounds such as polyphenols and other plant metabolites. Antioxidant compounds could play a major role in the prevention of some chronic diseases related to oxidative stress. However, as has been demonstrated recently, a great number of these bioactive molecules escape gastrointestinal digestion and reach the large intestine where gut microbes have the necessary enzymatic equipment to metabolize them. As a result, many different (usually smaller) compounds are released and can potentially be absorbed. Accordingly, the antioxidant capacity of the original food may well be very different from what is actually absorbed. Therefore, knowing how gut microbiota can modify the antioxidant capacity of the original food will provide valuable information that could change our current perceptions of highly or barely antioxidant food.

We invite you to submit your latest research findings or a review article to this Special Issue, which will bring together current research concerns related to the effect that gut microbiota could have on the antioxidant capacity of foods. Research articles can be based on either in vitro or in vivo experimental designs. Articles can include information about specific metabolite transformation by gut microbiota, the absorption process, metabolite quantification and identification, antioxidant capacity assays, sequencing data (metagenomic or metatranscriptomic), and metabolic routes, among others.

Dr. Sergio Pérez Burillo
Prof. Dr. José Ángel Rufián-Henares
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • antioxidant capacity
  • antioxidant molecules
  • polyphenols
  • gut microbiota
  • microbial metabolites

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Published Papers (1 paper)

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Research

26 pages, 13506 KiB  
Article
Biombalance™, an Oligomeric Procyanidins-Enriched Grape Seed Extract, Prevents Inflammation and Microbiota Dysbiosis in a Mice Colitis Model
by Mohamed Mokrani, Naima Saad, Ludivine Nardy, Elodie Sifré, Julie Despres, Amandine Brochot, Christine Varon and Maria C. Urdaci
Antioxidants 2025, 14(3), 305; https://doi.org/10.3390/antiox14030305 - 1 Mar 2025
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Abstract
Inflammatory bowel disease (IBD) results from genetic factors, environmental factors, and intestinal microbiota interactions. This study investigated the effects of Biombalance™ (BB) in dextran sulphate sodium (DSS)-induced colitis in mice. BB extract exhibits high antioxidant activity, as determined by DPPH and ORAC tests. [...] Read more.
Inflammatory bowel disease (IBD) results from genetic factors, environmental factors, and intestinal microbiota interactions. This study investigated the effects of Biombalance™ (BB) in dextran sulphate sodium (DSS)-induced colitis in mice. BB extract exhibits high antioxidant activity, as determined by DPPH and ORAC tests. Mice were fed a standard diet, and BB was administered by gavage for ten days, before administration of 2.75% DSS in drinking water. BB significantly protected mice against DSS effects, as assessed by colon length, disease activity index (DAI) scores and colonic pathological damage. In addition, BB inhibited the expression of proinflammatory markers, such as IL-6, IL-17, CXCL1 and TNF-α, and the inflammatory mediators iNOS, TGF-β, FoxP3 and F4/80, while increasing IL-10 expression in the colon. BB modified microbiota composition, attenuating the microbial diversity lost due to DSS, increasing beneficial bacteria like Muribaculum, Lactobacillus, Muscispirillum, Roseburia and Bifidobacterium, and decreasing potentially harmful bacteria such as Proteobacteria and Enterococcus. Interestingly, microbiota-predicted functions using PICRUSt revealed that BB extract increases the antioxidant superpathway of ubiquinol biosynthesis, including ubiquinol-7, 8, 9 and 10 (CoenzymesQ). These findings suggest that Biombalance™ administration may help to reduce gut inflammation and oxidation, at least partly through modifications of the microbiota and its metabolites. Full article
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