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Special Issue "Hypoxia and Oxidative Stress"
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "ROS, RNS and RSS".
Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 7201
Special Issue Editors
Interests: hypoxia; redox signaling; oxidative stress; NADPH oxidases
Interests: hypoxia; reactive oxygen species; oxidative stress; organism; cardiovascular, inflammatory and tumor diseases
Special Issue Information
Hypoxia and the generation of reactive oxygen species (ROS) share a toxic dependency on each other. Both can be considered as types of redox stress—hypoxia is a result of lack of oxygen, whereas increased levels of ROS can result from increased levels of oxygen. Additionally, in cases of reoxygenation, hypoxia leads to an increase of ROS generation. There are various sources of ROS, of which there are three main types. One main source is the respiratory chain of the mitochondria, which produces increased numbers of ROS, especially in the presence of an excess of oxygen or after reoxygenation. Another source is the uncoupled NO synthase resulting from a lack of amino acids, which can be a result of hypoxia. The third source is the family of NADPH oxidases, enzymes whose only function is to generate ROS, such as superoxides and hydrogen peroxide. Several components of the NADPH oxidases are activated by the family of HIF transcription factors. However, the HIF transcription factors are also redox-sensitive themselves and can be activated by non-hypoxic redox processes. Despite considerable progress in understanding this relationship between hypoxia and ROS, the big picture regarding different physiological or pathophysiological conditions is only partly understood.
With this Special Issue, we want to shed light on this field. Therefore, we kindly invite you to submit your latest research findings or reviews covering two aspects in particular—new knowledge of the mechanisms and pathways involved in the generation and actions of ROS under or after hypoxia and under physiological and pathophysiological conditions, and new knowledge of regulations of mediators of hypoxic pathways in which ROS are involved. Additionally, papers describing new methods that can be used to detect and distinguish different types of ROS under hypoxic conditions are welcomed. We believe this Special Issue will offer a snapshot of the current knowledge of the interplay between ROS and hypoxia, which will not only include important current advances, but will also be a worthwhile resource for researchers worldwide wanting to deepen their knowledge in this field.
We look forward to your contributions and will be happy to discuss your suggestions.
Dr. Andreas Petry
Prof. Dr. Agnes Görlach
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- oxidative stress
- respiratory chain
- uncoupled NO synthase
- NADPH oxidases