Mitochondrial Dysfunction in Corneal Diseases

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 1740

Special Issue Editor


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Guest Editor
School of Optometry, Indiana University, Bloomington, IN, USA
Interests: cornea; corneal endothelium; corneal endothelial dystrophies

Special Issue Information

Dear Colleagues,

Mitochondrial dysfunction has been implicated in corneal endothelial dystrophies, keratoconus, and dry eye. The cornea is exposed to UV light and high oxygen tension, making it more susceptible to oxidative stress and mitochondrial dysfunction. This Special Issue, titled Mitochondrial Dysfunction in Corneal Diseases, aims to reveal the latest advances in understanding the role of mitochondrial dysfunction in corneal disease. What are the mechanisms that trigger mitochondrial dysfunction in these diseases? How does mitochondrial dysfunction inform the pathological phenotype? What are the possible therapies that can be used to target the mitochondria? Original papers and focused reviews are sought contributions.

Dr. Diego Ogando
Guest Editor

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Keywords

  • mitochondrial dysfunction 
  • oxidative stress 
  • corneal dystrophy 
  • antioxidant

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Published Papers (1 paper)

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Research

13 pages, 2717 KiB  
Article
Far-Ultraviolet C Disinfection Reduces Oxidative Damage to the Cornea Compared to Povidone-Iodine Disinfection
by Tu-Wen Chen, Rong-Kung Tsai, Cheng-En Zou, Chin-Te Huang, Maisam Ali, Tzu-Chao Hsu, Keh-Liang Lin and Yao-Tseng Wen
Antioxidants 2024, 13(11), 1344; https://doi.org/10.3390/antiox13111344 - 1 Nov 2024
Viewed by 1405
Abstract
Far-ultraviolet C (far-UVC) light shows promise for pathogen control but its safety and efficacy for corneal disinfection remain unclear. In this study, safe far-UVC dosages were investigated for corneal disinfection and its germicidal performance and oxidative damage potential to 5% povidone-iodine (PVP-I) were [...] Read more.
Far-ultraviolet C (far-UVC) light shows promise for pathogen control but its safety and efficacy for corneal disinfection remain unclear. In this study, safe far-UVC dosages were investigated for corneal disinfection and its germicidal performance and oxidative damage potential to 5% povidone-iodine (PVP-I) were compared. Rat corneas were exposed to varying 222 nm far-UVC doses (3–60 mJ/cm2) and assessed for ocular damage, apoptosis, and oxidative stress to determine the safe dose of far-UVC. Far-UVC at 30 mJ/cm2 induced corneal apoptosis and oxidative damage, but 15 mJ/cm2 caused no apoptosis or oxidative damage. At this optimized dose (9 mJ/cm2), far-UVC achieved 90.5% sterilization, exceeding 5% PVP-I (80.8%), with significantly less oxidative damage and cell death in the cornea. In conclusion, our study demonstrates that the use of 5% povidone-iodine (PVP-I) for disinfection results in significant oxidative damage to the corneal tissue. However, a safe dosage of far-UVC light exhibited a promising disinfection effect without causing oxidative damage to the corneal tissue. Far-UVC offers a promising alternative for corneal disinfection but requires careful dosage control (≤30 mJ/cm2) to avoid ocular surface harm. Full article
(This article belongs to the Special Issue Mitochondrial Dysfunction in Corneal Diseases)
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