Special Issue "Role of Flavonoids on Cell Signalling Pathways"
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: closed (31 August 2019).
Interests: flavonoid cellular effects; oxidative stress; inflammation; NFkB and Nrf2 signalling; gene regulation; mitochondria; functional foods
The group of flavonoids has attracted our interest over many years; however, we are still lacking a detailed understanding of basic mechanisms to fully explain their beneficial properties. Flavonoids and some of their metabolites have been shown to affect key cell signalling pathways, demonstrating their involvement in a number of cell functions, e.g., related to redox signalling, inflammation, and metabolic regulation. Mechanisms are likely to involve direct interactions of flavonoids with proteins, including transcription factors and nuclear receptors, and their impact on gene regulatory networks as well as affinities for membrane association relating to subcellular localization and targeted effects in mitochondria or nucleus. Recent findings on the importance of gut derived flavonoid metabolites has added an additional layer to this complex topic.
This Special Issue welcomes recent original findings and reviews on the following aspects of this topic:
- Mechanistic studies on flavonoids on different cellular signalling pathways (in vitro and in vivo)
- Flavonoid-protein and receptor interactions, identification of cellular binding proteins
- Subcellular location, e.g., mitochondria interactions, and consequences for cell signalling
- Differential effects of flavonoid subgroups and their (gut) metabolites on signalling and function
- Flavonoid effects on epigenetic mechanisms
Dr. Christine Bosch
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Flavonoid modulation of gene expression
- Cell signalling pathways
- Flavonoid targets: protein/receptor interaction
- Cellular flavonoid metabolism
- Flavonoids and epigenetics