Special Issue "Role of Flavonoids on Cell Signalling Pathways"
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: closed (31 August 2019) | Viewed by 11290
Interests: flavonoid cellular effects; oxidative stress; inflammation; NFkB and Nrf2 signalling; gene regulation; mitochondria; functional foods
The group of flavonoids has attracted our interest over many years; however, we are still lacking a detailed understanding of basic mechanisms to fully explain their beneficial properties. Flavonoids and some of their metabolites have been shown to affect key cell signalling pathways, demonstrating their involvement in a number of cell functions, e.g., related to redox signalling, inflammation, and metabolic regulation. Mechanisms are likely to involve direct interactions of flavonoids with proteins, including transcription factors and nuclear receptors, and their impact on gene regulatory networks as well as affinities for membrane association relating to subcellular localization and targeted effects in mitochondria or nucleus. Recent findings on the importance of gut derived flavonoid metabolites has added an additional layer to this complex topic.
This Special Issue welcomes recent original findings and reviews on the following aspects of this topic:
- Mechanistic studies on flavonoids on different cellular signalling pathways (in vitro and in vivo)
- Flavonoid-protein and receptor interactions, identification of cellular binding proteins
- Subcellular location, e.g., mitochondria interactions, and consequences for cell signalling
- Differential effects of flavonoid subgroups and their (gut) metabolites on signalling and function
- Flavonoid effects on epigenetic mechanisms
Dr. Christine Bosch
Manuscript Submission Information
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- Flavonoid modulation of gene expression
- Cell signalling pathways
- Flavonoid targets: protein/receptor interaction
- Cellular flavonoid metabolism
- Flavonoids and epigenetics