Mitochondrial and Redox Signaling in Exercise, Aging, and Metabolic Health
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 21
Special Issue Editors
Interests: metabolic in physical exercise and training; nutrition supplements; reactive oxygen
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Maintaining redox homeostasis and mitochondrial function is essential for cellular plasticity, physical performance, and healthy aging. The balance between redox signaling and mitochondrial metabolism regulates physiological adaptations to exercise, nutritional status, and metabolic or environmental challenges. When these regulatory pathways are disturbed, the risk of sarcopenia, metabolic dysfunction, osteoporosis, and other age-related or neurodegenerative diseases increases substantially.
This Special Issue aims to highlight the integrative role of redox and mitochondrial pathways as molecular regulators connecting exercise, metabolic function, and neuromuscular health across the lifespan.
We welcome original research and review articles addressing molecular, cellular, and translational aspects of redox biology in the context of exercise, aging, neurodegeneration, and metabolic regulation.
We encourage submissions from researchers working at the intersection of molecular biology, physiology, and clinical research.
Topics of interest include, but are not limited to, the following:
- Redox signaling and mitochondrial regulation in exercise adaptation, fatigue, and neuroprotection;
- Mitochondrial biogenesis and quality control in aging skeletal muscle and brain;
- Exercise-induced modulation of antioxidant defenses, neurotrophic signaling, and metabolic health;
- Redox control of myokine, osteokine, and neurotrophic factor activity;
- Vitamin D-dependent regulation of redox balance in muscle, bone, and neuro-metabolic crosstalk;
- Oxidative stress, inflammation, and mitochondrial dysfunction in sarcopenia, osteoporosis, and neurodegenerative diseases;
- Nutritional and pharmacological interventions targeting mitochondrial and redox pathways in the regulation of the muscle–brain axis;
- Redox biomarkers and translational perspectives in exercise, aging, and neurodegenerative diseases.
Dr. Jan Jacek Kaczor
Guest Editor
Dr. Mateusz Jakub Karnia
Guest Editor Assistant
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mitochondria
- skeletal muscle
- exercise
- aging
- metabolism
- oxidative stress
- muscle–brain crosstalk
- sarcopenia
- osteoporosis
- neurodegenerative diseases
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