Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidative Stress
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 3290
Special Issue Editor
Interests: redox signaling, antioxidants, cardiovascular diseases, hypertension, endothelial dysfunction, natural products, aging, pulmonary hypertension
Special Issue Information
Dear Colleagues,
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. CVDs are linked to a number of risk factors, including smoking, high cholesterol, and high blood glucose levels. CVDs include hypertension, stroke, heart failure, and myocardial infarction, among others. The endothelium plays a major role in cardiovascular physiology. At the cellular level, endothelial dysfunction is a critical factor in the development of CVDs. Endothelial dysfunction also appears to be involved in the early stages of CVDs, including age-related CVDs. Aging-related changes to the heart and blood vessels may increase a person's risk of developing CVDs. Furthermore, aging can lead to CVDs, and as global life expectancy rises so will the prevalence of CVDs. Surprisingly, oxidative stress has been linked to endothelial dysfunction, aging-related endothelial dysfunction, and various CVDs.
ROS (reactive oxygen species) are a pleiotropic class of compounds with a wide range of oxidized properties that affect many genes and proteins at the physiological level. This signaling can be disrupted, resulting in cellular dysfunction and illness. Although oxidative stress and endothelial dysfunction are typically found in hypertensive individuals, new evidence suggests that they may play a causal role in the molecular mechanisms that contribute to hypertension. Substances that modulate redox signaling, reduce or attenuate oxidative stress, and target antioxidant genes, enzymes, and transcription factors are therefore essential for preventing or treating CVDs in both young and older people. Furthermore, recent studies demonstrate that endothelial dysfunction and injury in the vascular wall can be repaired by endothelial progenitor cells.
As a result of the above, this Special Issue welcomes original research papers or review articles focusing on the primary mechanisms underlying oxidative stress and how it leads to endothelial dysfunction and CVDs, as well as the beneficial role that natural products may play in endothelial dysfunction-related CVDs.
Prof. Dr. Isac Almeida de Medeiros
Guest Editor
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Keywords
- endothelial dysfunction
- endothelial progenitor cells
- cardiovascular diseases
- aging
- oxidative stress
- redox signaling
- dna damage
- hypertension
- antioxidant system
- natural products
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