Nitric Oxide (NO) and Hydrogen Sulfide (H2S) in Biology, Illness, and Therapies—2nd Edition
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "ROS, RNS and RSS".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 2546
Special Issue Editor
Interests: nitric oxide; hydrogen sulfide; persulfide/polysulfide; sulfur metabolism; redox reaction; interaction/crosstalk; antioxidants; disease; therapy; detection methods
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In light of the great response that we received to our previous Special Issue, "Nitric Oxide (NO) and Hydrogen Sulfide (H2S) in Biology, Illness, and Therapies", we decided to revisit this topic.
Gaseous signaling molecules, including nitric oxide (NO), carbon dioxide (CO), and hydrogen sulfide (H2S), have been emerging as physiologically and pathophysiologically important mediators in mammals. Manipulating these mediators as a therapeutic measure appears promising in various diseases, and has already, at least partly, enhanced their clinical application, mostly through the inhalation of NO. The manipulation of H2S or persulfide/polysulfide, oxidative products of H2S, is being explored in clinical trials. However, these therapies still face challenges regarding broader clinical application, such as their toxicity, rapid diffusion, short half-life, and narrow therapeutic window. Novel therapeutic methods or strategies are required to enable more successful clinical applications for these gaseous mediators. These mediators or their metabolites also crosstalk/interact with each other and could exhibit nonspecific diverse reactions, which complicate our understanding of the biology of gaseous mediators and remain to be elucidated.
In this Special Issue, we welcome original research articles or review articles that focus on the physiology/pathophysiology, therapies, detection methods, and redox reactions related to NO, H2S, and their metabolites, facilitating the establishment of novel therapies for illnesses.
Dr. Eizo Marutani
Guest Editor
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Keywords
- nitric oxide
- hydrogen sulfide
- persulfide/polysulfide
- sulfur metabolism
- redox reaction
- interaction/crosstalk
- antioxidants
- disease
- therapy
- detection methods
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