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Nitric Oxide (NO) and Hydrogen Sulfide (H2S) in...
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Nitric Oxide (NO) and Hydrogen Sulfide (H2S) in Biology, Illness, and Therapies—2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "ROS, RNS and RSS".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 2434

Special Issue Editor

Dr. Eizo Marutani

E-Mail Website
Guest Editor
Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
Interests: nitric oxide; hydrogen sulfide; persulfide/polysulfide; sulfur metabolism; redox reaction; interaction/crosstalk; antioxidants; disease; therapy; detection methods
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In light of the great response that we received to our previous Special Issue, "Nitric Oxide (NO) and Hydrogen Sulfide (H2S) in Biology, Illness, and Therapies", we decided to revisit this topic.

Gaseous signaling molecules, including nitric oxide (NO), carbon dioxide (CO), and hydrogen sulfide (H2S), have been emerging as physiologically and pathophysiologically important mediators in mammals. Manipulating these mediators as a therapeutic measure appears promising in various diseases, and has already, at least partly, enhanced their clinical application, mostly through the inhalation of NO. The manipulation of H2S or persulfide/polysulfide, oxidative products of H2S, is being explored in clinical trials. However, these therapies still face challenges regarding broader clinical application, such as their toxicity, rapid diffusion, short half-life, and narrow therapeutic window. Novel therapeutic methods or strategies are required to enable more successful clinical applications for these gaseous mediators. These mediators or their metabolites also crosstalk/interact with each other and could exhibit nonspecific diverse reactions, which complicate our understanding of the biology of gaseous mediators and remain to be elucidated.

In this Special Issue, we welcome original research articles or review articles that focus on the physiology/pathophysiology, therapies, detection methods, and redox reactions related to NO, H2S, and their metabolites, facilitating the establishment of novel therapies for illnesses.

Dr. Eizo Marutani
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nitric oxide
  • hydrogen sulfide
  • persulfide/polysulfide
  • sulfur metabolism
  • redox reaction
  • interaction/crosstalk
  • antioxidants
  • disease
  • therapy
  • detection methods

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Published Papers (2 papers)

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12 pages, 1833 KiB  
Article
Antihypertensive Effects of a Sodium Thiosulfate-Loaded Nanoparticle in a Juvenile Chronic Kidney Disease Rat Model
by You-Lin Tain, Chien-Ning Hsu, Chih-Yao Hou and Chih-Kuang Chen
Antioxidants 2024, 13(12), 1574; https://doi.org/10.3390/antiox13121574 - 20 Dec 2024
Viewed by 829
Abstract
Sodium thiosulfate (STS), a precursor of hydrogen sulfide (H2S), has demonstrated antihypertensive properties. Previous studies have suggested that H2S-based interventions can prevent hypertension in pediatric chronic kidney disease (CKD). However, the clinical application of STS is limited by its [...] Read more.
Sodium thiosulfate (STS), a precursor of hydrogen sulfide (H2S), has demonstrated antihypertensive properties. Previous studies have suggested that H2S-based interventions can prevent hypertension in pediatric chronic kidney disease (CKD). However, the clinical application of STS is limited by its rapid release and intravenous administration. To address this, we developed a poly-lactic acid (PLA)-based nanoparticle system for sustained STS delivery and investigated whether weekly treatment with STS-loaded nanoparticles (NPs) could protect against hypertension in a juvenile CKD rat model. Male Sprague Dawley rats, aged three weeks, were fed a diet containing 0.5% adenine for three weeks to induce a model of pediatric CKD. STS-loaded NPs (25 mg/kg) were administered intravenously during weeks 6, 7, and 8, and at week 9, all rats were sacrificed. Treatment with STS-loaded NPs reduced systolic and diastolic blood pressure by 10 mm Hg and 8 mm Hg, respectively, in juvenile CKD rats. The protective effect of STS-loaded NPs was linked to increased renal expression of H2S-producing enzymes, including cystathionine γ-lyase (CSE) and D-amino acid oxidase (DAO). Additionally, STS-loaded NP therapy restored nitric oxide (NO) signaling, increasing L-arginine levels, which were disrupted in CKD. Furthermore, the beneficial effects of STS-loaded NPs were associated with inhibition of the renin–angiotensin system (RAS) and the enhancement of the NO signaling pathway. Our findings suggest that STS-loaded NP treatment provides sustained STS delivery and effectively reduces hypertension in a juvenile CKD rat model, bringing us closer to the clinical translation of STS-based therapy for pediatric CKD-induced hypertension. Full article
(This article belongs to the Special Issue Nitric Oxide (NO) and Hydrogen Sulfide (H2S) in Biology, Illness, and Therapies—2nd Edition)
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14 pages, 2756 KiB  
Article
Chondroitin Sulfate Ameliorates Hypertension in Male Offspring Rat Born to Mothers Fed an Adenine Diet
by You-Lin Tain, Chih-Yao Hou, Guo-Ping Chang-Chien, Shu-Fen Lin and Chien-Ning Hsu
Antioxidants 2024, 13(8), 944; https://doi.org/10.3390/antiox13080944 - 2 Aug 2024
Viewed by 1186
Abstract
Pregnant women with chronic kidney disease (CKD) face increased risks of adverse outcomes in their adult offspring. Offspring rats born to dams fed an adenine diet develop hypertension, coinciding with dysregulated hydrogen sulfide (H2S) and nitric oxide (NO) pathways, as well [...] Read more.
Pregnant women with chronic kidney disease (CKD) face increased risks of adverse outcomes in their adult offspring. Offspring rats born to dams fed an adenine diet develop hypertension, coinciding with dysregulated hydrogen sulfide (H2S) and nitric oxide (NO) pathways, as well as alterations in gut microbiota. Chondroitin sulfate (CS) is a multifunctional food known for its diverse bioactivities. As a sulfate prebiotic, CS has shown therapeutic potential in various diseases. Here, we investigated the protective effects of maternal CS supplementation against hypertension in offspring induced by an adenine diet. Mother rats were administered regular chow, 0.5% adenine, 3% CS, or a combination throughout gestation and lactation. Maternal CS supplementation effectively protected offspring from hypertension induced by the adenine diet. These beneficial effects of CS were connected with increased renal mRNA and protein levels of 3-mercaptopyruvate sulfurtransferase, an enzyme involved in H2S production. Furthermore, maternal CS treatment significantly enhanced alpha diversity and altered beta diversity of gut microbiota in adult offspring. Specifically, perinatal CS treatment promoted the abundance of beneficial microbes such as Roseburia hominis and Ruminococcus gauvreauii. In conclusion, perinatal CS treatment mitigates offspring hypertension associated with maternal adenine diet, suggesting that early administration of sulfate prebiotics may hold preventive potential. These findings warrant further translational research to explore their clinical implications. Full article
(This article belongs to the Special Issue Nitric Oxide (NO) and Hydrogen Sulfide (H2S) in Biology, Illness, and Therapies—2nd Edition)
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