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Antioxidants
Special Issues
Recent Trends in Nanoantioxidants
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Recent Trends in Nanoantioxidants

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 11254

Special Issue Editors

Dr. Maria Letizia Manca

E-Mail Website
Guest Editor
Department of Life and Environmental Sciences, University of Cagliari, 09042 Monserrato, Italy
Interests: cosmetics and cosmeceuticals; phytochemicals delivery; liposomes; phospholipid vesicles; antioxidants; antiaging; regenerative treatments; polyphenols; natural chemicals from agri-food by-products; keratinocytes; fibro-blasts; macrophages; in vitro testing; skin hydration; skin elasticity; in vivo clinical trials
Special Issues, Collections and Topics in MDPI journals
Dr. Matteo Perra

E-Mail Website
Guest Editor
Biomedical & Tissue Engineering Laboratory, Fundacion Investigacion Hospital General Universitario Valencia, Valencia, Spain
Interests: drug delivery; nano carriers; antioxidants; pharmaceutical technology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is well known that certain lifestyle choices and the intake of unhealthy chemicals lead to an overproduction of reactive oxygen species (ROS), which are one of the major causes of several inflammatory acute or chronic diseases and also cancer. Their overproduction causes oxidative damage, which can result in inflammation, DNA damage and other complications.

Antioxidant compounds can counteract oxidative damage by scavenging a wide range of reactive oxygen species. However, both natural and synthetic compounds, but especially those of natural origin, are characterized by several stability issues, such as photosensitivity, poor water solubility and low bioavailability, limiting their in vivo application.

To overcome these problems, nowadays, research aims to develop the most suitable systems to deliver antioxidant compounds to the organism by improving their properties. Among these, nanotechnology represents the best candidate. The scope of all the nano drug delivery systems is to reduce the size of the active principles to the nano level to improve their solubility. After obtaining nanosized compounds, the formulation may proceed with the development of more complex systems such as liposomes or liposome-like systems, solid lipid nanoparticles (SLNs), nanoemulsions and nanostructured lipid carriers (NLCs), which can circulate in the body, promoting and improving their bioavailability.

This Special Issue, “Recent Trends in Nano Antioxidants”, aims to provide an overview of the recent advances in nano drug delivery compounds with antioxidant properties, including, but not necessarily restricted to, natural molecules.

Dr. Maria Letizia Manca
Dr. Matteo Perra
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanocarriers
  • liposomes
  • nanocrystals
  • oxidative stress
  • inflammation
  • antioxidant
  • cosmeceuticals
  • nutraceuticals
  • ROS
  • liposomes
  • nanosystems

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Published Papers (6 papers)

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Editorial

Jump to: Research, Review

3 pages, 165 KiB  
Editorial
Recent Trends in Nanoantioxidants
by Matteo Perra and Maria Letizia Manca
Antioxidants 2025, 14(2), 207; https://doi.org/10.3390/antiox14020207 - 12 Feb 2025
Viewed by 576
Abstract
The term “oxidative stress” refers to an imbalance between reactive oxygen species (ROS) generation and the antioxidant system, resulting in the increased formation of ROS and the reduced and/or inadequate efficiency of the physiological processes responsible for their elimination and homeostasis maintenance [...] [...] Read more.
The term “oxidative stress” refers to an imbalance between reactive oxygen species (ROS) generation and the antioxidant system, resulting in the increased formation of ROS and the reduced and/or inadequate efficiency of the physiological processes responsible for their elimination and homeostasis maintenance [...] Full article
(This article belongs to the Special Issue Recent Trends in Nanoantioxidants)

Research

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19 pages, 5654 KiB  
Article
Fullerenol C60(OH)36: Antioxidant, Cytoprotective, Anti-Influenza Virus Activity, and Self-Assembly in Aqueous Solutions and Cell Culture Media
by Alina A. Borisenkova, Mikhail Y. Eropkin, Nadezhda I. Konovalova, Anna V. Titova, Maria A. Markova, Zhanna B. Lyutova, Anton S. Mazur, Victor P. Sedov, Vera A. Orlova, Anna N. Lykholay, Diana N. Orlova and Alexandr V. Arutyunyan
Antioxidants 2024, 13(12), 1525; https://doi.org/10.3390/antiox13121525 - 13 Dec 2024
Cited by 2 | Viewed by 1323
Abstract
Viral infections and many other dangerous diseases are accompanied by the development of oxidative stress, which is a consequence of an increase in the level of the reactive oxygen species (ROS). In this regard, the search for effective antioxidants remains highly relevant. We [...] Read more.
Viral infections and many other dangerous diseases are accompanied by the development of oxidative stress, which is a consequence of an increase in the level of the reactive oxygen species (ROS). In this regard, the search for effective antioxidants remains highly relevant. We tested fullerenol C60(OH)36 in the context of the connection between its self-assembly in aqueous solutions and cell culture media, antiradical activity, UV cytoprotective action, and antiviral activity against international reference strains of influenza virus A(H1N1)pdm09, A(H3N2), and B subtypes in vitro on the MDCK cell line. Various characterization techniques, including Fourier-transform infrared spectroscopy (FTIR), Raman spectroscopy, NMR and ESR spectrometry, MALDI-TOF mass spectrometry, thermal analysis (TGA and DSC), dynamic light-scattering (DLS), and ζ-potential measurements, were used to confirm the production of fullerenol and study its self-assembly in aqueous solutions and cell culture media. Fullerenol C60(OH)36 demonstrated the ability to scavenge •DPPH, •OH, O2•− radicals and 1O2 and was non-toxic in the range of the studied concentrations (up to 200 μg/mL) when incubated with MDCK cells for 24 h. In addition, fullerenol exhibited a cytoprotective effect under UV irradiation (EC50 = 29.7 ± 1.0 μM) and showed moderate activity against human influenza viruses of subtypes A(H1N1)pdm09 (SI = 9.9 ± 4.6) and A(H3N2) (SI = 12.5 ± 1.3) when determined by the hemagglutination assay (HA-test) and the MTT assay. At the same time, C60(OH)36 was ineffective in vitro against the actual strain of influenza B virus (Victoria lineage). The high bioavailability of fullerenol in combination with its cytoprotective effect, as well as its antiradical and antiviral activity combined with a relatively low toxicity, allows to consider it a promising compound for biomedical applications. Full article
(This article belongs to the Special Issue Recent Trends in Nanoantioxidants)
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23 pages, 6882 KiB  
Article
Intratracheal Administration of Stem Cell Membrane-Cloaked Naringin-Loaded Biomimetic Nanoparticles Promotes Resolution of Acute Lung Injury
by Hua Jin, Yue Zhao, Yinlian Yao, Shilong Fan, Renxing Luo, Xin Shen, Yanyan Wang, Jiang Pi and Gonghua Huang
Antioxidants 2024, 13(3), 282; https://doi.org/10.3390/antiox13030282 - 26 Feb 2024
Cited by 3 | Viewed by 2380
Abstract
Cytokine storm and ROS overproduction in the lung always lead to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in a very short time. Effectively controlling cytokine storm release syndrome (CRS) and scavenging ROS are key to the prevention and treatment [...] Read more.
Cytokine storm and ROS overproduction in the lung always lead to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in a very short time. Effectively controlling cytokine storm release syndrome (CRS) and scavenging ROS are key to the prevention and treatment of ALI/ARDS. In this work, the naringin nanoparticles (Nar-NPs) were prepared by the emulsification and evaporation method; then, the mesenchymal stem cell membranes (CMs) were extracted and coated onto the surface of the Nar-NPs through the hand extrusion method to obtain the biomimetic CM@Nar-NPs. In vitro, the CM@Nar-NPs showed good dispersity, excellent biocompatibility, and biosafety. At the cellular level, the CM@Nar-NPs had excellent abilities to target inflamed macrophages and the capacity to scavenge ROS. In vivo imaging demonstrated that the CM@Nar-NPs could target and accumulate in the inflammatory lungs. In an ALI mouse model, intratracheal (i.t.) instillation of the CM@Nar-NPs significantly decreased the ROS level, inhibited the proinflammatory cytokines, and remarkably promoted the survival rate. Additionally, the CM@Nar-NPs increased the expression of M2 marker (CD206), and decreased the expression of M1 marker (F4/80) in septic mice, suggesting that the Nar-modulated macrophages polarized towards the M2 subtype. Collectively, this work proves that a mesenchymal stem cell membrane-based biomimetic nanoparticle delivery system could efficiently target lung inflammation via i.t. administration; the released payload inhibited the production of inflammatory cytokines and ROS, and the Nar-modulated macrophages polarized towards the M2 phenotype which might contribute to their anti-inflammation effects. This nano-system provides an excellent pneumonia-treated platform with satisfactory biosafety and has great potential to effectively deliver herbal medicine. Full article
(This article belongs to the Special Issue Recent Trends in Nanoantioxidants)
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29 pages, 5504 KiB  
Article
H2S-Synthesizing Enzymes Are Putative Determinants in Lung Cancer Management toward Personalized Medicine
by Ana Hipólito, Cindy Mendes, Filipa Martins, Isabel Lemos, Inês Francisco, Fernando Cunha, Teresa Almodôvar, Cristina Albuquerque, Luís G. Gonçalves, Vasco D. B. Bonifácio, João B. Vicente and Jacinta Serpa
Antioxidants 2024, 13(1), 51; https://doi.org/10.3390/antiox13010051 - 28 Dec 2023
Cited by 2 | Viewed by 2294
Abstract
Lung cancer is a lethal disease with no truly efficient therapeutic management despite the progresses, and metabolic profiling can be a way of stratifying patients who may benefit from new therapies. The present study is dedicated to profiling cysteine metabolic pathways in NSCLC [...] Read more.
Lung cancer is a lethal disease with no truly efficient therapeutic management despite the progresses, and metabolic profiling can be a way of stratifying patients who may benefit from new therapies. The present study is dedicated to profiling cysteine metabolic pathways in NSCLC cell lines and tumor samples. This was carried out by analyzing hydrogen sulfide (H2S) and ATP levels, examining mRNA and protein expression patterns of cysteine catabolic enzymes and transporters, and conducting metabolomics analysis using nuclear magnetic resonance (NMR) spectroscopy. Selenium–chrysin (SeChry) was tested as a therapeutic alternative with the aim of having an effect on cysteine catabolism and showed promising results. NSCLC cell lines presented different cysteine metabolic patterns, with A549 and H292 presenting a higher reliance on cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) to maintain H2S levels, while the PC-9 cell line presented an adaptive behavior based on the use of mercaptopyruvate sulfurtransferase (MST) and cysteine dioxygenase (CDO1), both contributing to the role of cysteine as a pyruvate source. The analyses of human lung tumor samples corroborated this variability in profiles, meaning that the expression of certain genes may be informative in defining prognosis and new targets. Heterogeneity points out individual profiles, and the identification of new targets among metabolic players is a step forward in cancer management toward personalized medicine. Full article
(This article belongs to the Special Issue Recent Trends in Nanoantioxidants)
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17 pages, 3696 KiB  
Article
Evaluating Antioxidant Performance, Biosafety, and Antimicrobial Efficacy of Houttuynia cordata Extract and Microwave-Assisted Synthesis of Biogenic Silver Nano-Antibiotics
by Kavya Moorthy, Kai-Chih Chang, Hsiao-Chi Huang, Wen-Jui Wu and Cheng-Kang Chiang
Antioxidants 2024, 13(1), 32; https://doi.org/10.3390/antiox13010032 - 22 Dec 2023
Cited by 1 | Viewed by 2512
Abstract
From the traditional Chinese medicine point of view, although Houttuynia cordata extract (HCE) possesses an incredible amount of phytonutrients and exhibits antioxidant activities, excessive doses of HCE can cause danger to organisms and lead to death. In this study, we first examine HCE’s [...] Read more.
From the traditional Chinese medicine point of view, although Houttuynia cordata extract (HCE) possesses an incredible amount of phytonutrients and exhibits antioxidant activities, excessive doses of HCE can cause danger to organisms and lead to death. In this study, we first examine HCE’s overall phenolic and flavonoid content, antioxidant efficacy, and antibacterial activity. Results show that HCE is suitable as a bio-reducing agent for the microwave-assisted synthesis of silver nanoparticles (HCE-AgNPs) with enhanced antioxidant and antimicrobial performance. Under an optimized microwave condition (i.e., 100 °C for 10 min), the HCE-stabilized AgNPs were confirmed with a UV-visible peak at 430 nm and 19.7 ± 4.2 nm in size. Physicochemical properties of HCE-AgNPs were extensively characterized by zeta-potential, FT-IR, XRD, and XPS measurements. Compared to the HC extract counterpart, HCE-AgNPs display superior antioxidant activity, higher DPPH scavenging efficiency, and enhanced broad-spectrum bactericidal activity to inhibit the growth of all tested bacterial strains at doses of 2 μg/mL. Biosafety evaluation indicated that HCE-AgNPs are noncytotoxic on human red blood cells. These data show that the microwave synthesis of AgNPs exhibits a great antioxidant ability, superior antibacterial activity, and a trivial hemolytic effect, providing another bactericidal therapy strategy to address the increasing healthcare-associated infections. Full article
(This article belongs to the Special Issue Recent Trends in Nanoantioxidants)
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Review

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27 pages, 15212 KiB  
Review
Recent Trends in the Development and Application of Nano-Antioxidants for Skin-Related Disease
by Yi Xue, Tao Wang, Ji-Peng Liu, Qi Chen, Xiao-Long Dai, Min Su, Yu-Hang Cheng, Cheng-Chao Chu and Yun-Qing Ren
Antioxidants 2025, 14(1), 27; https://doi.org/10.3390/antiox14010027 - 28 Dec 2024
Viewed by 1055
Abstract
Skin is a vital barrier for the human body, protecting against external environmental influences and maintaining internal homeostasis. In addition, an imbalance of oxidative stress and antioxidant mechanisms can lead to skin-related diseases. Thus, for treating skin-related diseases, antioxidant therapy may be an [...] Read more.
Skin is a vital barrier for the human body, protecting against external environmental influences and maintaining internal homeostasis. In addition, an imbalance of oxidative stress and antioxidant mechanisms can lead to skin-related diseases. Thus, for treating skin-related diseases, antioxidant therapy may be an important strategy to alleviate these symptoms. However, traditional drug therapies have limitations in treating these conditions, such as lack of lasting effect and insufficient skin permeability. Recently, nano-antioxidants, with their good permeability, sustained-release ability, multifunctionality, and other beneficial characteristics, have showed their advances in the exploration of skin-related diseases from research on safe therapies to clinical practice. Hereby, we review the latest research and advancements in nano-antioxidants for skin-related diseases. We categorize skin-related diseases into four main groups: skin inflammatory diseases, skin damage caused by ultraviolet rays, skin wound healing, and other skin-related conditions. Additionally, we summarize the prospects and potential future directions for nano-antioxidant drugs in treating skin-related diseases. Full article
(This article belongs to the Special Issue Recent Trends in Nanoantioxidants)
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