Phytotherapy and Natural Products in the Treatment and Prevention of Chronic Diseases
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 62
Special Issue Editors
Interests: dietary antioxidants; reactive oxygen species (ROS); nephrotoxicity; molecular biology; pharmacology; toxicology
Special Issues, Collections and Topics in MDPI journals
Interests: hematological cancers; leukemia; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic diseases—including cardiovascular and neurodegenerative disorders diabetes and cancer—pose significant global health challenges. Mounting scientific evidence underscores the pivotal role of oxidative stress and chronic inflammation in their pathogenesis. In this context, there is growing interest in phytotherapy and natural products, particularly those rich in antioxidants, as promising agents for both prevention and adjunctive treatment.
This research topic invites original contributions that investigate the efficacy of plant-derived compounds—such as polyphenols, flavonoids, terpenoids, and alkaloids—in mitigating oxidative damage and restoring physiological homeostasis. We also welcome studies that elucidate the cellular and molecular mechanisms by which traditional and herbal medicinal plants modulate oxidative stress, inflammation, aging, and related diseases.
To better define the scope of this topic, we encourage submissions that explore specific mechanisms of action, including the modulation of redox-sensitive signaling pathways (e.g., Nrf2/ARE, NF-κB), enhancement of endogenous antioxidant defenses (e.g., SOD, catalase, glutathione), and inhibition of pro-inflammatory mediators. While the list of plant components is broad, not all classes of compounds are equally involved in oxidative stress mitigation; therefore, studies should clearly delineate the bioactive constituents responsible for the observed effects and their mechanistic relevance.
Submissions integrating multi-omics approaches with experimental validation are especially encouraged. Authors are expected to provide a comprehensive description of the plant materials used, including methods of identification, extraction, and processing. For detailed submission requirements, please consult the author guidelines.
Prof. Dr. Sara Damiano
Prof. Dr. Roberto Ciarcia
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- chronic diseases
- phytotherapy
- natural antioxidants
- plant-derived compounds
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