Antioxidant Activity of Olive Extracts and Their Applications

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: closed (30 June 2025) | Viewed by 913

Special Issue Editors


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Guest Editor
Department of Food Phytochemistry, Instituto de la Grasa (Spanish National Research Council, CSIC), Pablo Olavide University, Building 46, Ctra de Utrera km 1, 41013 Seville, Spain
Interests: bioactive molecules; olive; alperujo; extraction processes; phenol–polysaccharide complex; antioxidant dietary fiber; phenolic compounds; modified pectin; flow cytometry; antiproliferative activity; anti-inflammatory activity; cancer
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Guest Editor
Instituto de la Grasa, Consejo Superior de Investigaciones Científicas (CSIC), Campus Universitario Pablo de Olavide, Edificio 46, Ctra. de Utrera, km 1, 41013 Seville, Spain
Interests: olive oil; bioactive molecules; antioxidants; structural characterization; biological activity

Special Issue Information

Dear Colleagues,

Olive extracts obtained from oil, fruit, leaves, wood, or waste are recognized for their extensive health benefits, such as reducing hypertension and diabetes and preventing cardiovascular diseases and cancer. These effects are mainly attributed to the high content of antioxidants in olive products, including polyphenols (phenolic acids, flavonoids, lignans, and secoiridoid derivatives), carotenoids (xanthophylls and β-carotene), chlorophylls, pheophytins, and α-tocopherol (vitamin E), which mitigate oxidative stress caused by free radicals and subsequent cellular damage. Recent research has highlighted the importance of polysaccharide–polyphenol complexes that form during the crushing and malaxation of olive paste prior to oil extraction, offering significant nutritional and antioxidant benefits. Consequently, olive extracts have attracted considerable attention and inspired ongoing investigations centred around their health effects, analytical methods, extraction efficiencies, and diverse applications.

We invite contributions presenting recent findings, covering all aspects of olive extract research. Manuscripts discussing the antioxidant properties of olive extracts, their mechanisms of action, and their potential health benefits are particularly welcome. While we encourage studies on the development and optimization of both traditional and innovative extraction methods, we are particularly interested in recent advances in the applications of these extracts.

In the pharmaceutical industry, olive extracts are being explored for their potential in preventing and treating chronic diseases due to their bioactive compounds. The food industry also benefits from the use of olive extracts as natural preservatives and health-promoting additives, enhancing the nutritional profile and shelf life of food products. Furthermore, olive extracts are increasingly used in nutraceuticals and functional foods aimed at improving overall health and wellness.

Dr. Alejandra Bermudez-Oria
Dr. Fátima Rubio-Senent
Guest Editors

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Keywords

  • olive extracts
  • antioxidant activity
  • polyphenols
  • carotenoids
  • chlorophylls
  • tocopherol
  • oxidative stress
  • cellular damage prevention
  • health benefits
  • extraction methods
  • green extraction techniques
  • nutritional applications
  • cosmetic applications

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Published Papers (1 paper)

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Research

17 pages, 2607 KiB  
Article
Unveiling the Cardioprotective Potential of Hydroxytyrosol: Insights from an Acute Myocardial Infarction Model
by Alejandra Bermúdez-Oria, Eugenia Godoy, Virginia Pérez, Camila Musci Ferrari, Martin Donato, Juan Fernández-Bolaños, Tamara Zaobornyj and Verónica D’Annunzio
Antioxidants 2025, 14(7), 803; https://doi.org/10.3390/antiox14070803 - 28 Jun 2025
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Abstract
Cardiovascular diseases remain the leading cause of death worldwide, highlighting the urgent need for novel therapeutic strategies. The Mediterranean diet is renowned for its cardiovascular benefits, largely attributed to extra virgin olive oil (EVOO) and its phenolic compounds, particularly hydroxytyrosol (HT). HT, a [...] Read more.
Cardiovascular diseases remain the leading cause of death worldwide, highlighting the urgent need for novel therapeutic strategies. The Mediterranean diet is renowned for its cardiovascular benefits, largely attributed to extra virgin olive oil (EVOO) and its phenolic compounds, particularly hydroxytyrosol (HT). HT, a potent antioxidant and anti-inflammatory agent, has demonstrated significant therapeutic potential in mitigating myocardial damage following acute myocardial infarction (AMI). However, there is a notable lack of published evidence regarding the effects of HT administration in the context of acute ischemia/reperfusion (I/R) injury, making this study a novel contribution to the field. This study aimed to evaluate the cardioprotective effects of HT using the Langendorff technique in an isolated mouse heart ischemia/reperfusion (I/R) model. Mice were administered a single intraperitoneal dose of HT (10 mg/kg) 24 h prior to the I/R protocols, and parameters such as the infarct size, mitochondrial function, and redox balance were assessed. The results revealed a remarkable 57% reduction in infarct size in HT-treated mice compared to untreated controls. HT treatment also improved mitochondrial bioenergetics, as evidenced by the increased membrane potential (ΔΨm), enhanced oxygen consumption, and reduced hydrogen peroxide (H2O2) production. Furthermore, HT restored the activity of the mitochondrial respiratory complexes, notably Complex I, even under I/R conditions. These findings highlight the efficacy of HT in reducing oxidative stress and preserving mitochondrial function, critical factors in cardiac disease. In conclusion, HT emerges as a promising therapeutic agent for ischemic heart disease, demonstrating both preventive and restorative potential. Future research should explore its clinical applicability to advance cardiovascular disease management. Full article
(This article belongs to the Special Issue Antioxidant Activity of Olive Extracts and Their Applications)
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