Redox-Based Targeting of Signaling Pathways as a Therapeutic Approach
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 1911
Special Issue Editors
Interests: reactive sulfur species
Special Issue Information
Dear Colleagues,
The field of redox regulation has been developing considerably, with research increasingly highlighting its critical role in human health and disease. It is well established that physiological processes are tightly governed by cellular signaling pathways, which control cell metabolism, survival, and growth. Although numerous studies have demonstrated that redox regulation influences signaling pathways, research on the substances specifically targeting redox signaling as a therapeutic approach remains limited.
Emerging evidence suggests that the dysregulation of cellular signaling significantly contributes to ageing and pathological processes in various conditions, including cancer, neurological disorders, cardiovascular diseases, metabolic malfunctions, ischemia–reperfusion injury, and even senescence. Thus, therapeutic strategies based on modulating such signaling pathways provide promising interventions. Several natural compounds or small molecules have been identified as potential activators or inhibitors of signaling pathways and are currently under investigation in preclinical and clinical settings. Notably, some cellular signaling regulators are considered redox-sensitive molecules, including kinases (e.g., AMPK, MAPKs), phosphatases (e.g., PTPs), or transcription factors (e.g., Nrf2, NF-κB). In contrast with nonspecific ROS-scavenging therapy, the selective modulation of these redox-sensitive proteins or enzymes may offer a more precise and effective approach.
In this Special Issue, we focus on advances in the redox-based modality of treatment that target associated cellular signaling pathways.
Prof. Dr. Seung-rock Lee
Guest Editor
Dr. Dhiraj Kumar Sah
Guest Editor Assistant
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Keywords
- cellular signaling
- redox-based
- therapeutic intervention
- human disease
- longevity
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