Redox-Based Targeting of Signaling Pathways as a Therapeutic Approach
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 70
Special Issue Editors
Interests: reactive sulfur species
Special Issue Information
Dear Colleagues,
The field of redox regulation has been developing considerably, with research increasingly highlighting its critical role in human health and disease. It is well established that physiological processes are tightly governed by cellular signaling pathways, which control cell metabolism, survival, and growth. Although numerous studies have demonstrated that redox regulation influences signaling pathways, research on the substances specifically targeting redox signaling as a therapeutic approach remains limited.
Emerging evidence suggests that the dysregulation of cellular signaling significantly contributes to ageing and pathological processes in various conditions, including cancer, neurological disorders, cardiovascular diseases, metabolic malfunctions, ischemia–reperfusion injury, and even senescence. Thus, therapeutic strategies based on modulating such signaling pathways provide promising interventions. Several natural compounds or small molecules have been identified as potential activators or inhibitors of signaling pathways and are currently under investigation in preclinical and clinical settings. Notably, some cellular signaling regulators are considered redox-sensitive molecules, including kinases (e.g., AMPK, MAPKs), phosphatases (e.g., PTPs), or transcription factors (e.g., Nrf2, NF-κB). In contrast with nonspecific ROS-scavenging therapy, the selective modulation of these redox-sensitive proteins or enzymes may offer a more precise and effective approach.
In this Special Issue, we focus on advances in the redox-based modality of treatment that target associated cellular signaling pathways.
Prof. Dr. Seung-rock Lee
Guest Editor
Dr. Dhiraj Kumar Sah
Guest Editor Assistant
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cellular signaling
- redox-based
- therapeutic intervention
- human disease
- longevity
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
