Antioxidants and Food Supplements

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 2206

Special Issue Editor


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Guest Editor
Department of Pharmacy, University of Naples Federico II, Via Montesano 49, 80149 Naples, Italy
Interests: mechanism of action of antioxidants; interaction food and genes; cell biology; nutraceuticals; food supplements; metabolic syndrome
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Special Issue Information

Dear Colleagues,

Oxidative stress is caused by an imbalance between free radicals and antioxidants in the body and poses a significant threat to cellular integrity and overall health. This Special Issue focuses on the pivotal role of antioxidants and food supplements in combating oxidative stress and its multifaceted impacts on cellular processes. The contributions within this issue explore various aspects, starting with elucidating natural sources of antioxidants and their mechanisms of action in mitigating oxidative damage. In addition, the broader implications of antioxidant activity beyond oxidative stress are explored, including interactions with different cellular pathways and their potential therapeutic relevance. Understanding these intricate links paves the way for innovative disease prevention and management approaches. Through a synthesis of original research and comprehensive reviews, this Special Issue offers valuable insights into the multifaceted role of antioxidants and food supplements in maintaining cellular homeostasis and enhancing health outcomes. Moreover, elucidating the intricate interplay between oxidative stress and cellular pathways provides a foundation for future research endeavors aimed at harnessing the therapeutic potential of antioxidants for improved health and longevity. We are pleased to invite research papers that deal with studies on in vitro or in vivo models and clinical trials with the main objective of expanding knowledge in this field and gaining new insights.

Prof. Dr. Mariano Stornaiuolo
Guest Editor

Manuscript Submission Information

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Keywords

  • food supplements
  • natural bioactive compound
  • antioxidants
  • oxidative stress
  • cellular pathways
  • nutraceuticals
  • free radicals
  • health outcomes
  • disease prevention

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Published Papers (2 papers)

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Research

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17 pages, 7557 KiB  
Article
Ameliorative Effects of HT074-Inula and Paeonia Extract Mixture on Acute Reflux Esophagitis in Rats via Antioxidative Activity
by Young-Sik Kim, Yeonjin Park, Yongbin Kim, Hyo-Eun Son, Jinhui Rhee, Chang-Won Pyun, Chanoh Park and Hocheol Kim
Antioxidants 2024, 13(8), 891; https://doi.org/10.3390/antiox13080891 - 23 Jul 2024
Cited by 1 | Viewed by 1119
Abstract
HT074, a multiherbal mixture containing extracts from Inula britannica flowers and Paeonia lactiflora roots, is used in Korean medicine for gastric disorders. This study investigated the protective mechanisms of HT074 against acute reflux esophagitis (RE) in rats. Nitric oxide (NO) production and mRNA [...] Read more.
HT074, a multiherbal mixture containing extracts from Inula britannica flowers and Paeonia lactiflora roots, is used in Korean medicine for gastric disorders. This study investigated the protective mechanisms of HT074 against acute reflux esophagitis (RE) in rats. Nitric oxide (NO) production and mRNA expression of antioxidant-related genes (Nrf2, HO-1, SOD, CAT, and GPx2) were evaluated in LPS-induced RAW 264.7 cells. Gastroesophageal reflux (GER) was induced in rats, followed by HT074 (100, 300 mg/kg) or ranitidine (50 mg/kg) administration. Esophageal damage and histological changes were assessed. Gastric pH and protein expression levels of Nrf2, HO-1, SOD, CAT, and GPx-1/2 were measured. HT074 pretreatment reduced NO production and increased the expression of HO-1, CAT, and GPx2 in LPS-induced RAW 264.7 cells. In GER-induced rats, HT074 significantly decreased esophageal lesions and increased the expression of HO-1, SOD, GPx-1/2, and Nrf2. HT074 did not affect gastric pH. These findings suggest that HT074 protects against GER-induced esophagitis by inhibiting NO production and enhancing antioxidant activity. Therefore, HT074 could be a promising therapeutic agent for GER disease. Full article
(This article belongs to the Special Issue Antioxidants and Food Supplements)
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Review

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24 pages, 5318 KiB  
Review
Mechanistic Insights and Analytical Advances in Food Antioxidants: A Comprehensive Review of Molecular Pathways, Detection Technologies, and Nutritional Applications
by Mingyu Duan, Zhiting Zhu, Hao Pi, Jibing Chen, Jie Cai and Yiping Wu
Antioxidants 2025, 14(4), 438; https://doi.org/10.3390/antiox14040438 - 4 Apr 2025
Viewed by 445
Abstract
With rising living standards, the demand for health and nutrition has increased, sparking interest in food antioxidants. Known for neutralizing free radicals, antioxidants protect cells from oxidative damage, potentially aiding in disease prevention and anti-aging. In the food industry, they also enhance preservation [...] Read more.
With rising living standards, the demand for health and nutrition has increased, sparking interest in food antioxidants. Known for neutralizing free radicals, antioxidants protect cells from oxidative damage, potentially aiding in disease prevention and anti-aging. In the food industry, they also enhance preservation and quality. Thus, studying food antioxidant mechanisms, detection methods, and applications holds theoretical and practical value. This review mainly discusses the mechanisms, detection methods, and applications of food antioxidants in nutrition. Firstly, the main research status and development trends of food antioxidants are described. Then, the action mechanisms of food antioxidants are introduced. Food antioxidants can effectively remove free radicals and prevent free radicals from causing damage to human cells, thus delaying aging and preventing disease. Secondly, the methods of detecting food antioxidants are discussed, including liquid chromatography, liquid chromatography–tandem mass spectrometry, gas chromatography, and gas chromatography–mass spectrometry. These methods can be used to analyze antioxidant components in various samples of foods, drugs, plants, etc. Finally, the research progress of plant antioxidants is discussed, including the applications of a variety of highly effective antioxidant components extracted from different plants. This review provides the theoretical basis and application reference for the research of food antioxidants. Full article
(This article belongs to the Special Issue Antioxidants and Food Supplements)
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