Role of Skeletal Muscle and Exercise in Oxidative Stress-Related Diseases
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (28 February 2026) | Viewed by 2140
Special Issue Editor
Special Issue Information
Dear Colleagues,
We invite researchers, clinicians, and interdisciplinary experts to contribute original research articles, comprehensive reviews, and short communications to this Special Issue.
Oxidative stress plays a key role in the development of many chronic diseases, including metabolic syndrome, nonalcoholic fatty liver disease, type 2 diabetes, cardiovascular disorders, sarcopenia, and neurodegenerative conditions. Skeletal muscle, which is highly metabolically active and rich in redox-sensitive pathways, is a central target and active regulator of systemic oxidative stress. Exercise is a non-pharmacological intervention that provides significant benefits by influencing redox homeostasis, muscle adaptation, and systemic health. This makes exercise a promising area of research for disease prevention and management.
This Special Issue aims to explore and expand knowledge across the following key areas:
(1) The molecular and cellular mechanisms by which oxidative stress affects skeletal muscle function, regeneration, and degeneration, including mitochondrial dysfunction, redox signaling, inflammation, proteostasis imbalance, and apoptosis.
(2) Exercise-induced adaptations in skeletal muscle under oxidative stress conditions, such as mitochondrial biogenesis, antioxidant responses, muscle-fiber-type switching, autophagy, and hormetic regulation.
(3) The identification of novel biomarkers, therapeutic targets, and regulatory pathways connecting oxidative stress to muscle health has implications for diagnosis, prognosis, and personalized interventions.
(4) Translational and clinical perspectives on the modulation of muscle physiology by redox, especially in aging populations, patients with chronic diseases, and individuals with varying physical activity levels.
(5) Comparative analysis of the effects of different exercise modalities, including endurance, resistance, and high-intensity interval training, on skeletal muscle redox status and functional outcomes in health and disease contexts.
(6) The development of integrated therapeutic strategies combining exercise with pharmacological or nutritional approaches to optimize oxidative stress control and promote muscle health.
We welcome multidisciplinary contributions from the fields of molecular biology, physiology, clinical research, biochemistry, sports science, rehabilitation, and public health.
Prof. Dr. Sechang Oh
Guest Editor
Manuscript Submission Information
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Keywords
- oxidative stress
- skeletal muscle
- exercise
- physical activity
- redox biology
- chronic disease prevention
- muscle adaptation
- biomarkers of oxidative stress
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