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Most Cited

  • Review
  • Open Access
35 Citations
14,262 Views
19 Pages

Pathophysiology of Red Blood Cell Dysfunction in Diabetes and Its Complications

  • Alyssa Williams,
  • Rosi Bissinger,
  • Hala Shamaa,
  • Shivani Patel,
  • Lavern Bourne,
  • Ferruh Artunc and
  • Syed M. Qadri

Diabetes Mellitus (DM) is a complex metabolic disorder associated with multiple microvascular complications leading to nephropathy, retinopathy, and neuropathy. Mounting evidence suggests that red blood cell (RBC) alterations are both a cause and con...

  • Review
  • Open Access
30 Citations
18,973 Views
23 Pages

Pathophysiology, Management, and Therapeutics in Subarachnoid Hemorrhage and Delayed Cerebral Ischemia: An Overview

  • Henry W. Sanicola,
  • Caleb E. Stewart,
  • Patrick Luther,
  • Kevin Yabut,
  • Bharat Guthikonda,
  • J. Dedrick Jordan and
  • J. Steven Alexander

Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke resulting from the rupture of an arterial vessel within the brain. Unlike other stroke types, SAH affects both young adults (mid-40s) and the geriatric population. Patients with SAH often...

  • Review
  • Open Access
29 Citations
13,633 Views
19 Pages

In recent years, the elderly has become a rapidly growing proportion of the world’s population as life expectancy is extending. Immunosenescence and inflammaging contribute to the increased risk of chronic non-communicable and acute infectious...

  • Review
  • Open Access
23 Citations
5,790 Views
20 Pages

Cells employ a well-preserved physiological stress response mechanism, termed the heat shock response, to activate a certain type of molecular chaperone called heat shock proteins (HSPs). HSPs are activated by transcriptional activators of heat shock...

  • Review
  • Open Access
21 Citations
17,421 Views
25 Pages

Neuromodulation and the Gut–Brain Axis: Therapeutic Mechanisms and Implications for Gastrointestinal and Neurological Disorders

  • Baha’ Aljeradat,
  • Danisha Kumar,
  • Sulaiman Abdulmuizz,
  • Mrinmoy Kundu,
  • Yasser F. Almealawy,
  • Dima Ratib Batarseh,
  • Oday Atallah,
  • Michelle Ennabe,
  • Muath Alsarafandi and
  • Albert Alan
  • + 1 author

The gut–brain axis (GBA) represents a complex, bidirectional communication network that intricately connects the gastrointestinal tract with the central nervous system (CNS). Understanding and intervening in this axis opens a pathway for therap...

  • Feature Paper
  • Article
  • Open Access
17 Citations
3,221 Views
13 Pages

Hormone Replacement Therapy Does Not Eliminate Risk Factors for Joint Complications following Total Joint Arthroplasty: A Matched Cohort Study

  • Lacee K. Collins,
  • Matthew W. Cole,
  • Timothy L. Waters,
  • Michael Iloanya,
  • Patrick A. Massey and
  • William F. Sherman

Aging causes a reduction in testosterone and estrogen, which is linked to diminished bone mineral density. Hormone replacement therapy and its effect on the outcome of joint arthroplasties is unclear. The purpose of this study was to analyze the impa...

  • Article
  • Open Access
16 Citations
3,654 Views
11 Pages

This study aims to investigate the effect of resveratrol on systemic inflammatory response and metabolic disorder in rats fed a high-fructose high-lipid diet (HFHLD) and exposed to round-the-clock lighting (RCL). 21 adult male Wistar rats were random...

  • Review
  • Open Access
15 Citations
4,340 Views
21 Pages

Gut Microbiome Changes in Anorexia Nervosa: A Comprehensive Review

  • Wendi Zhao,
  • Prabhath Kodancha and
  • Soumitra Das

Anorexia nervosa (AN) remains a challenging condition in psychiatric management and its pathogenesis is not yet fully understood. An imbalance in the gut microbiota composition may contribute to its pathophysiology. This review aims to explore the li...

  • Review
  • Open Access
14 Citations
4,703 Views
22 Pages

Gut Microbiome Interactions with Oxidative Stress: Mechanisms and Consequences for Health

  • Natalya Semenova,
  • Nadezhda Garashchenko,
  • Sergey Kolesnikov,
  • Marina Darenskaya and
  • Liubov Kolesnikova

Understanding how gut flora interacts with oxidative stress has been the subject of significant research in recent years. There is much evidence demonstrating the existence of the microbiome–oxidative stress interaction. However, the biochemica...

  • Review
  • Open Access
14 Citations
8,057 Views
12 Pages

Surgical Management of Traumatic Meniscus Injuries

  • Hannah R. Popper,
  • Brian E. Fliegel,
  • Dawn M. Elliott and
  • Alvin W. Su

The menisci increase the contact area of load bearing in the knee and thus disperse the mechanical stress via their circumferential tensile fibers. Traumatic meniscus injuries cause mechanical symptoms in the knee, and are more prevalent amongst youn...

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Pathophysiology - ISSN 1873-149X