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Medical Sciences Forum, Volume 14, Issue 1

2022 ECMC 2022 - 151 articles

The 8th International Electronic Conference on Medicinal Chemistry

Online | 1–30 November 2022

Volume Editors:
Alfredo Berzal-Herranz, Instituto de Parasitología y Biomedicina López-Neyra, (IPBLN-CSIC), Spain
Maria Emília Sousa, Universidade do Porto, Portugal

Cover Story: This volume presents a collection of contributions that were made to the virtual event “The 8th International Electronic Conference on Medicinal Chemistry” on 1–30 November 2022. The main topics are all related to a wide range of aspects involved in drug discovery and development: small molecules as drug candidates; biomolecules, natural products, phages, and cells as therapeutic tools; biological targets and biomarkers, etc. We hope this volume can provide new references and provoke fresh ideas for scholars in the field of medicinal chemistry and drug-related sciences.
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Articles (151)

  • Abstract
  • Open Access
1 Citations
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2 Pages
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Targeted Delivery of Doxorubicin to Breast Cancer Cells by Multiwalled Carbon Nanotubes Functionalized with Lysine via 1,3-Dipolar Cycloaddition and Conjugation with Sugar Moieties

  • Chanchal Kiran Thakur,
  • Chandrabose Karthikeyan,
  • Subhasmita Bhal,
  • Chanakya Nath Kundu and
  • Narayana Subbiah Hari Narayana Moorthy
Med. Sci. Forum2022, 14(1), 140;https://doi.org/10.3390/ECMC2022-13421

1 November 2022

Multiwalled carbon nanotubes (MWCNTs) have attracted considerable multidisciplinary interest and biomedical applications, such as drug delivery, because of their distinct physicochemical characteristics. The biomedical application of MWCNTs is limite...

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1,314 Views
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β-Cyclodextrins as Carriers for the Targeted Delivery of Pharmaceutical Substances against Lipase from Malassezia spp.

  • Viktor Andreevich Filatov
Med. Sci. Forum2022, 14(1), 141;https://doi.org/10.3390/ECMC2022-13497

7 November 2022

Seborrheic dermatitis (SD) and dandruff are the most prevalent scalp diseases in populations around the world. The main etiopathogenetic factor of these diseases is an altered abundance of Malassezia species that secrete several lipases and turn acyl...

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The Synthesis and Biological Activity of Amidrazone Derivatives Obtained in Reaction with cis-1,2,3,6-Tetrahydrophthalic Anhydride

  • Renata Paprocka,
  • Małgorzata Wiese-Szadkowska,
  • Jolanta Kutkowska and
  • Adam Kowalewski
Med. Sci. Forum2022, 14(1), 139;https://doi.org/10.3390/ECMC2022-13453

1 November 2022

Amidrazones are known for the broad biological activity of their derivatives (antimicrobial, anti-inflammatory, antiparasitic, antitumor and others). While searching for new drugs, twelve new derivatives of N3-substituted amidrazones were obtained in...

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Annonaceous Acetogenins Reported for the First Time in the Leaves and Fruit’s Pulp of Annona atemoya

  • Bassam S. M. Al Kazman,
  • Joanna E. Harnett and
  • Jane Rouse Hanrahan
Med. Sci. Forum2022, 14(1), 138;https://doi.org/10.3390/ECMC2022-13444

1 November 2022

Annona atemoya is a commercially important fruiting plant belonging to the Annonaceae family. It is widely cultivated in tropical and subtropical continents. It is also known as the custard apple which is a hybrid between two Annonaceae species, thos...

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1 Citations
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Box–Behnken Assisted HPLC Development of Simultaneous Determination of Doxorubicin and Vorinostat Encapsulated into Polymeric Nanoparticles

  • Maria Sokol,
  • Ivan Gulyaev,
  • Mariia Mollaeva,
  • Sergey Kuznetsov,
  • Vladimir Zenin,
  • Maksim Klimenko,
  • Nikita Yabbarov,
  • Margarita Chirkina and
  • Elena Nikolskaya
Med. Sci. Forum2022, 14(1), 136;https://doi.org/10.3390/ECMC2022-13493

7 November 2022

The objects of the present study are nanoparticles (NPs) based on a copolymer of lactic and glycolic acids (PLGA), loaded with the anticancer drug doxorubicin (DOX-NP) and histone deacetylase inhibitor vorinostat (SAHA-NP) and developed for breast ca...

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1,051 Views
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Extraction of Anthocyanins from Black Currants and In Vitro Testing for the Determination of Antioxidant Activity

  • Veronica Popa,
  • Sorin Avramescu and
  • Miruna Silvia Stan
Med. Sci. Forum2022, 14(1), 137;https://doi.org/10.3390/ECMC2022-13146

1 November 2022

Black currants have antioxidant, anti-inflammatory and chemoprotective properties. Anthocyanins, which are components of black currants, are powerful antioxidants that are able to inhibit the growth of tumor cells and induce apoptosis. In this contex...

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1,488 Views
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Development of In Situ Gel Containing Phytoconstituents for the Treatment of Mouth Ulcers

  • Kevinkumar Garala and
  • Parag Rabara
Med. Sci. Forum2022, 14(1), 135;https://doi.org/10.3390/ECMC2022-13438

1 November 2022

An ulcer that develops on the mucosal surface of the oral cavity is known as a mouth ulcer, also known as an oral ulcer or a mucosal ulcer. A mucus membrane ulcer is an open sore that is distinguished by the removal of inflammatory dead tissue. The m...

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1,033 Views
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Exploratory Studies on Anticancer Potential of a Vernonia Species against Colorectal Adenocarcinoma: In Vitro Studies and In Silico Mechanistic Investigations

  • Radhika K. Raheja and
  • Arundhati Nachiket Abhyankar
Med. Sci. Forum2022, 14(1), 134;https://doi.org/10.3390/ECMC2022-13456

1 November 2022

Globally, colorectal cancer (CRC) is amongst the most prevalent cancer incidences, being the second most common amongst women and third most common amongst men as revealed by ‘GLOBOCAN 2022’ statistics. The projected morbidity for CRC is...

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1,081 Views
2 Pages
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Design, Synthesis, and Biological Evaluation of New Benzoxaborole Derivatives as Potential Antimycobacterial Agents

  • Petr Šlechta,
  • Ondřej Jand’ourek,
  • Klára Konečná,
  • Pavla Paterová,
  • Pavel Bárta,
  • Vladimír Kubíček,
  • Martin Doležal and
  • Marta Kučerová-Chlupáčová
Med. Sci. Forum2022, 14(1), 133;https://doi.org/10.3390/ECMC2022-13454

1 November 2022

The current study is focused on the combination of pyrazinamide with 6-aminobenzo[c][1,2]oxaborol-1(3H)-ol, which is a crucial pharmacophore of several antimicrobial agents. The use of benzoxaborole moiety could afford the formation of a spiro adduct...

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  • Open Access
1 Citations
1,009 Views
1 Page
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In Silico Investigations of Dihydrophenanthrene Derivatives as Potential Inhibitors of SARS-CoV-2

  • Imane Yamari,
  • Suraj N. Mali,
  • Ossama Abchir,
  • Hassan Nour,
  • Said Gmouh,
  • M’Hammed El Kouali and
  • Samir Chtita
Med. Sci. Forum2022, 14(1), 121;https://doi.org/10.3390/ECMC2022-13293

1 November 2022

Since its appearance in Wuhan in December 2019, finding ways to manage the COVID-19 pandemic has become the biggest challenge the world is facing. In this investigation, we used a quantitative structure-activity relationship (QSAR) study, an absorpti...

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