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Abstract

Single Domain Magnetic Nanoparticles as Magneto-Mechanical Actuators for Remote Drug Release from Polyelectrolyte Microcapsules †

1
A.V. Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics”, Russian Academy of Sciences, 119333 Moscow, Russia
2
Department of Chemical Enzymology, Lomonosov Moscow State University, 119991 Moscow, Russia
3
Institute of Molecular Theranostics, I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia
*
Author to whom correspondence should be addressed.
Presented at the 8th International Electronic Conference on Medicinal Chemistry, 1–30 November 2022; Available online: https://ecmc2022.sciforum.net/.
Med. Sci. Forum 2022, 14(1), 90; https://doi.org/10.3390/ECMC2022-13495
Published: 7 November 2022
(This article belongs to the Proceedings of The 8th International Electronic Conference on Medicinal Chemistry)

Abstract

:
The modification of capsule shells with synthesized magnetic iron oxide nanoparticles aims not only to control the localization of capsules, but also to tune their permeability. The application of a super low frequency non-heating magnetic field (100 Hz) for these purposes offers prospects for high penetration ability into tissues, high locality, and safety, which makes this method preferable for use with in vivo rather than magnetic hyperthermia. In this work, we develop a proof of concept for the remotely controlled release of an encapsulated drug from polyelectrolyte microcapsules under exposure to an alternating super low frequency magnetic field. The characteristics of the tailor-made nanoparticles for the polyelectrolyte shell modification were analyzed to confirm their perspectives as magneto-mechanical actuators due to their abilities with the Brownian relaxation. Polyelectrolyte microcapsules were obtained using the well-known method of sequential deposition of polyelectrolytes on the surface of vaterite particles. We studied the time dependence of the amount of released fluorescently labeled high-molecular weight substance on the frequency of the applied magnetic field (100 mT, 20–100 Hz) and demonstrated that the application of a magnetic field with a frequency of 50 Hz leads to the most pronounced selective increase in the permeability of the shells. Our findings provide a promising application of composite magnetic microcapsules with permeability triggered by a super low frequency magnetic field for the controlled release of drugs without dangerous heating or overheating of the biological tissues. This work was supported by the grant of the President of the Russian Federation (MK-1109.2021.1.3).

Supplementary Materials

The following are available online at https://www.mdpi.com/article/10.3390/ECMC2022-13495/s1.

Author Contributions

Conceptualization, D.T. and N.K.; methodology, T.B.; investigation, I.B., M.V. and A.M.; validation, T.P.; data analysis, I.B.; writing—original draft preparation, D.T.; writing—review and editing, D.T. and T.P. All authors have read and agreed to the published version of the manuscript.

Funding

This research was funded by the grant of the President of the Russian Federation (MK-1109.2021.1.3).

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Not applicable.

Conflicts of Interest

The authors declare no conflict of interest.
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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MDPI and ACS Style

Burmistrov, I.; Veselov, M.; Mikheev, A.; Pallaeva, T.; Bukreeva, T.; Klyachko, N.; Trushina, D. Single Domain Magnetic Nanoparticles as Magneto-Mechanical Actuators for Remote Drug Release from Polyelectrolyte Microcapsules. Med. Sci. Forum 2022, 14, 90. https://doi.org/10.3390/ECMC2022-13495

AMA Style

Burmistrov I, Veselov M, Mikheev A, Pallaeva T, Bukreeva T, Klyachko N, Trushina D. Single Domain Magnetic Nanoparticles as Magneto-Mechanical Actuators for Remote Drug Release from Polyelectrolyte Microcapsules. Medical Sciences Forum. 2022; 14(1):90. https://doi.org/10.3390/ECMC2022-13495

Chicago/Turabian Style

Burmistrov, Ivan, Maxim Veselov, Alexander Mikheev, Tatiana Pallaeva, Tatiana Bukreeva, Natalia Klyachko, and Daria Trushina. 2022. "Single Domain Magnetic Nanoparticles as Magneto-Mechanical Actuators for Remote Drug Release from Polyelectrolyte Microcapsules" Medical Sciences Forum 14, no. 1: 90. https://doi.org/10.3390/ECMC2022-13495

APA Style

Burmistrov, I., Veselov, M., Mikheev, A., Pallaeva, T., Bukreeva, T., Klyachko, N., & Trushina, D. (2022). Single Domain Magnetic Nanoparticles as Magneto-Mechanical Actuators for Remote Drug Release from Polyelectrolyte Microcapsules. Medical Sciences Forum, 14(1), 90. https://doi.org/10.3390/ECMC2022-13495

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