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Abstract

Bimodal Nanoprobes Containing Hydrophilic Quantum Dots and Paramagnetic Chelates †

by
Rebeca Muniz de Melo
*,
Gabriela Marques Albuquerque
,
Giovannia Araújo de Lima Pereira
and
Maria Goreti Carvalho Pereira
Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife 50740-560, Brazil
*
Author to whom correspondence should be addressed.
Presented at the 8th International Electronic Conference on Medicinal Chemistry, 1–30 November 2022; Available online: https://ecmc2022.sciforum.net/.
Med. Sci. Forum 2022, 14(1), 114; https://doi.org/10.3390/ECMC2022-13307
Published: 1 November 2022
(This article belongs to the Proceedings of The 8th International Electronic Conference on Medicinal Chemistry)

Abstract

:
Currently, there is a growing interest in the development of bimodal systems that have a signal for more than one diagnostic imaging technique, such as magnetic resonance imaging (MRI). MRI is able to distinguish pathological from healthy tissues; however, in some cases, a high local concentration of contrast agents (CAs) is necessary to improve the contrast in images. Nanoparticulate CAs are able to concentrate several CA molecules into one nanoparticle, increasing the local concentrations of paramagnetic ions. In this work, we intend to associate AgInSe2 quantum dots (QDs) with gadolinium complexes (DOTA-Gd) to develop bimodal systems. The QDs were prepared in water and the synthesis parameters were optimized. The ligand DOTA was conjugated with cysteamine and complexed with Gd3+. The complex was then conjugated to QDs through the metal–thiol bond, obtaining the bimodal systems. Optical characterization indicated that the QDs remained stable and fluorescent, and an increase in emission intensity after conjugation was observed. The systems were characterized by relaxometry at 20 MHz (0.47 T) and 37 °C, obtaining longitudinal relaxivities by Gd3+ higher than the CAs used clinically. Thus, the prepared nanoprobes showed promising properties for MRI and optical imaging.

Supplementary Materials

The following are available online at https://www.mdpi.com/article/10.3390/ECMC2022-13307/s1.

Author Contributions

Conceptualization, G.M.A., G.A.d.L.P. and M.G.C.P.; methodology, R.M.d.M., G.M.A., G.A.d.L.P. and M.G.C.P.; formal analysis, R.M.d.M. and G.M.A.; investigation, R.M.d.M. and G.M.A.; resources, G.A.d.L.P. and M.G.C.P.; writing—original draft preparation, R.M.d.M. and G.M.A.; writing—review and editing, R.M.d.M., G.M.A., G.A.d.L.P. and M.G.C.P.; supervision, G.A.d.L.P. and M.G.C.P.; project administration, G.A.d.L.P. and M.G.C.P.; funding acquisition, G.A.d.L.P. and M.G.C.P. All authors have read and agreed to the published version of the manuscript.

Funding

This research was funded by UFPE/CNPq through the RM.M. scholarship (TI2110 004), and by FACEPE through the G.M.A. scholarship (IBPG-0985-3.03/20).

Informed Consent Statement

Not applicable.

Conflicts of Interest

The authors declare no conflict of interest.
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Share and Cite

MDPI and ACS Style

de Melo, R.M.; Albuquerque, G.M.; Pereira, G.A.d.L.; Pereira, M.G.C. Bimodal Nanoprobes Containing Hydrophilic Quantum Dots and Paramagnetic Chelates. Med. Sci. Forum 2022, 14, 114. https://doi.org/10.3390/ECMC2022-13307

AMA Style

de Melo RM, Albuquerque GM, Pereira GAdL, Pereira MGC. Bimodal Nanoprobes Containing Hydrophilic Quantum Dots and Paramagnetic Chelates. Medical Sciences Forum. 2022; 14(1):114. https://doi.org/10.3390/ECMC2022-13307

Chicago/Turabian Style

de Melo, Rebeca Muniz, Gabriela Marques Albuquerque, Giovannia Araújo de Lima Pereira, and Maria Goreti Carvalho Pereira. 2022. "Bimodal Nanoprobes Containing Hydrophilic Quantum Dots and Paramagnetic Chelates" Medical Sciences Forum 14, no. 1: 114. https://doi.org/10.3390/ECMC2022-13307

APA Style

de Melo, R. M., Albuquerque, G. M., Pereira, G. A. d. L., & Pereira, M. G. C. (2022). Bimodal Nanoprobes Containing Hydrophilic Quantum Dots and Paramagnetic Chelates. Medical Sciences Forum, 14(1), 114. https://doi.org/10.3390/ECMC2022-13307

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