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Volume 14
Issue 1
10.3390/ECMC2022-13143
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Abstract

The Journey towards Solubility Assessment of Small Molecules Using HPLC-DAD †

by
Nada Hemmani
,
Anaïs Cacilie Martin
,
Andy Larivière
,
Mathis Tresallet
,
Kensa Tchang
,
Isabelle Krimm
and
Marc Le Borgne
*
Small Molecules for Biological Targets Team, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Institut National de la Santé et de la Recherche Médicale (INSERM) 1052, Centre National de la Recherche Scientifique (CNRS) 5286, Université Claude Bernard Lyon 1, 69373 Lyon, France
*
Author to whom correspondence should be addressed.
†
Presented at the 8th International Electronic Conference on Medicinal Chemistry, 1–30 November 2022; Available online: https://ecmc2022.sciforum.net/.
Med. Sci. Forum 2022, 14(1), 62; https://doi.org/10.3390/ECMC2022-13143
Published: 1 November 2022
(This article belongs to the Proceedings of The 8th International Electronic Conference on Medicinal Chemistry)
Versions Notes

Abstract

:
In the process of developing bioactive small molecules, solubility determination is a crucial step. Many research papers treating problems related to solubility are published, but none of them fully describes the methods and steps for solubility assessment. In addition, in silico prediction tools and databases such as SwissADME, ACD/Percepta, DrugBank and many others offer the possibility to have approximative solubility values based on the structure of the molecule. Although significant differences can be observed depending on the database and the conditions of the experiment such as solvent, pH, temperature… etc. The lack of data can be a barrier to obtaining details on solubility measurement methods. This presentation aims to describe, step by step, the journey of tryptophan solubility determination using high-performance liquid chromatography-diode array detector (HPLC-DAD).

Supplementary Materials

The following are available online at https://www.mdpi.com/article/10.3390/ECMC2022-13143/s1.

Author Contributions

Conceptualization, I.K. and M.L.B.; methodology, N.H., A.C.M., A.L., M.T. and K.T.; investigation, M.T., A.L. and N.H.; supervision, M.L.B. All authors have read and agreed to the published version of the manuscript.

Funding

Marc Le Borgne and Isabelle Krimm would like to thank “Institut Convergence PLAsCAN” (ANR-17-CONV-0002).

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Not applicable.

Conflicts of Interest

The authors declare no conflict of interest.
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Hemmani, N.; Martin, A.C.; Larivière, A.; Tresallet, M.; Tchang, K.; Krimm, I.; Borgne, M.L. The Journey towards Solubility Assessment of Small Molecules Using HPLC-DAD. Med. Sci. Forum 2022, 14, 62. https://doi.org/10.3390/ECMC2022-13143

AMA Style

Hemmani N, Martin AC, Larivière A, Tresallet M, Tchang K, Krimm I, Borgne ML. The Journey towards Solubility Assessment of Small Molecules Using HPLC-DAD. Medical Sciences Forum. 2022; 14(1):62. https://doi.org/10.3390/ECMC2022-13143

Chicago/Turabian Style

Hemmani, Nada, Anaïs Cacilie Martin, Andy Larivière, Mathis Tresallet, Kensa Tchang, Isabelle Krimm, and Marc Le Borgne. 2022. "The Journey towards Solubility Assessment of Small Molecules Using HPLC-DAD" Medical Sciences Forum 14, no. 1: 62. https://doi.org/10.3390/ECMC2022-13143

APA Style

Hemmani, N., Martin, A. C., Larivière, A., Tresallet, M., Tchang, K., Krimm, I., & Borgne, M. L. (2022). The Journey towards Solubility Assessment of Small Molecules Using HPLC-DAD. Medical Sciences Forum, 14(1), 62. https://doi.org/10.3390/ECMC2022-13143

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