Development of Bioactive Molecules for the Treatment of Alzheimer’s Disease ^†

A series of novel thiophene pyrazolines were designed as potential bioactive molecules against Alzheimer’s disease. The probable binding modes of these molecules in AChE were evaluated using in silico techniques, and promising molecules were then synthesized and characterized. Their biological activities were profiled to confirm their potential as multifunctional molecules for the treatment of Alzheimer’s disease by addressing multiple pathological mechanisms. While the anti-oxidant activities of the synthesized molecules needed further optimization, the series showed excellent potential in mitigating the multiple causative factors via Aβ aggregation inhibition, AChE inhibition, metal chelation, and inhibition of advanced glycation products.