2026 December - 11 articles
Three 1-pyrrolidinyl 8-halo and one 1-pyrrolidinyl 8-cyano-substituted naphthalenes are prepared. The rate of the rotation of the pyrrolidinyl group is determined through variable temperature proton NMR using line-shape analysis and EXSY. The potenti...
Pladienolide B (1), a macrocyclic polyketide isolated from Streptomyces platensis Mer-11107, displays potent antiproliferative and antitumor activities through its interaction with the SF3b subunit of the spliceosome. Herein, we report a divergent, s...
The incorporation of ferrocene into established pharmacophores represents a promising strategy for combining targeted activity with the properties of the organometallic scaffold. Building on our previous work on ferrocene-modified tyrosine kinase inh...
Urolithin M7 is a gut microbial metabolite of ellagic acid, but its glucuronide conjugate has not been well characterized. We report the first total synthesis of urolithin M7 3-glucuronide through a convergent route that combines Pd-mediated intramol...
A series of five novel 3-methyl-1-phenyl-4-(4-thioaroyl)-pyrazol-5-ones is obtained in excellent yields by thionation of the corresponding O-analogues with Lawesson’s reagent. The products are characterized in solution and solid phase. It is fo...
Catalysis has been recognized as a key science in contemporary chemistry, owing to the significant potential of nanocatalysts and organic–inorganic hybrid materials, due to their high surface area and tunability properties, as well as the possi...
The influence of the counter anion and solvent on the N-heterocyclic carbene (NHC)-catalyzed nucleophilic aroylation of electron-deficient aromatic compounds was investigated using iodide, bis(trifluoromethanesulfonyl)imide (TFSA), and tetrafluorobor...
The amide macrocyclic complexes of zinc [ZnMc1, ZnMc2, and ZnMc3 (1–3)] were synthesized through template condensation of oxalic acid with different diamines, p-phenylenediamine, ethylenediamine, and propylenediamine, respectively. These zinc c...
Six ortho-substituted halogen derivatives (F, Cl, Br) of mono- and analog bisthiocarbohydrazones were synthesized and fully characterized. Structural characterization was performed through elemental analysis and NMR, FT-IR and UV-Vis spectroscopy. Al...
The development of environmentally sustainable synthetic approaches for biologically active heterocyclic compounds has become increasingly important in medicinal chemistry. In this study, two dihydropyrimidinone (DHPM) derivatives were synthesized th...
Betulin, a lupane-type pentacyclic triterpene abundant in birch bark, is an accessible renewable scaffold for semisynthetic chemistry, while its 3,28-diacetate serves both as an isolable derivative and as a protected intermediate for further function...
