Reports, Volume 9, Issue 1
2026 March - 94 articles
Cover Story: A 65-year-old woman with a partial Xq deletion, class 1 obesity, insulin resistance, prediabetes, hypercholesterolemia and metabolic dysfunction-associated steatotic liver disease reported persistent difficulty in managing excess body weight despite adherence to healthy lifestyle habits. We prescribed a combination therapy with low-dose metformin (500 mg/day) and once-weekly subcutaneous semaglutide (as an adjunct to lifestyle intervention). At 5 months, blood tests showed improvement in prediabetes management, in addition to normalization of markers of insulin sensitivity and insulin resistance. At 8 months, the patient achieved a percent total body weight loss of 20.95% (74.6% fat mass loss; 25.4% fat-free mass loss). Low-dose metformin and subcutaneous semaglutide (up to a weekly dose of 1.7 mg) were well tolerated by the patient. View this paper
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Reports - ISSN 2571-841X