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Absence of Interactions between Denosumab and Warfarin in Women with Osteoporosis

1
Unità Operativa Complessa Recupero e Riabilitazione, Grande Ospedale Metropolitano di Reggio Calabria, 89100 Reggio Calabria, Italy
2
Unità Operativa Semplice Dipartimentale Microcitemie Emostasi e Trombosi, Grande Ospedale Metropolitano di Reggio Calabria, 89100 Reggio Calabria, Italy
3
Clinica Nova Salus, 89010 Villa San Giovanni, Italy
4
Istituto di Ricovero e Cura a Carattere Scientifico Centro Neurolesi Bonino-Pulejo, 98100 Messina, Italy
*
Author to whom correspondence should be addressed.
Reports 2018, 1(3), 20; https://doi.org/10.3390/reports1030020
Received: 17 September 2018 / Revised: 22 October 2018 / Accepted: 23 October 2018 / Published: 26 October 2018
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Abstract

The monoclonal antibody denosumab reduces bone resorption. Warfarin is an oral anticoagulant used in the prevention and treatment of thrombosis. To date, there have been no studies on the interaction between warfarin and denosumab. The aim of the present study was to assess the maintenance of the Prothrombin Time International Normalized Ratio (INR) in the therapeutic range (TTR) in women under treatment with warfarin and denosumab, in order to evaluate the pharmacological interference of denosumab. No variations of the median TTR were found after undergoing treatment with denosumab: this shows that the intake of denosumab does not require additional checks in anticoagulated patients. View Full-Text
Keywords: osteporosis; denosumab; warfarin osteporosis; denosumab; warfarin
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Polimeni, V.; Sottilotta, G.; Branca, F.; Mammone, N.; Panuccio, A. Absence of Interactions between Denosumab and Warfarin in Women with Osteoporosis. Reports 2018, 1, 20.

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