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Keywords = osteporosis

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Article
Absence of Interactions between Denosumab and Warfarin in Women with Osteoporosis
by Vincenzo Polimeni, Gianluca Sottilotta, Fabiola Branca, Nadia Mammone and Antonio Panuccio
Reports 2018, 1(3), 20; https://doi.org/10.3390/reports1030020 - 26 Oct 2018
Viewed by 4619
Abstract
The monoclonal antibody denosumab reduces bone resorption. Warfarin is an oral anticoagulant used in the prevention and treatment of thrombosis. To date, there have been no studies on the interaction between warfarin and denosumab. The aim of the present study was to assess [...] Read more.
The monoclonal antibody denosumab reduces bone resorption. Warfarin is an oral anticoagulant used in the prevention and treatment of thrombosis. To date, there have been no studies on the interaction between warfarin and denosumab. The aim of the present study was to assess the maintenance of the Prothrombin Time International Normalized Ratio (INR) in the therapeutic range (TTR) in women under treatment with warfarin and denosumab, in order to evaluate the pharmacological interference of denosumab. No variations of the median TTR were found after undergoing treatment with denosumab: this shows that the intake of denosumab does not require additional checks in anticoagulated patients. Full article
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