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Proceedings 2017, 1(10), 1025;

Is There Any Protective Effect of Pomegranate and Tangeretin On The DMBA-Induced Rat Breast Cancer Model?

Department of Medical Biochemistry, Faculty of Medicine, Firat University, Elazig 23200, Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
Author to whom correspondence should be addressed.
Published: 10 November 2017
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The present study investigated the potential chemoprevention effects of Tangeretin (TAN) and Pomegranate (PE), both alone and in combination, on the oxidant-antioxidant status in 7,12-dimethylbenz [a] anthracene (DMBA)-evoked rat mammary carcinogenesis. Fifty-six female Sprague Dawley rats were divided into eight groups: Group I was control, Group II, III and IV were treated with pomegranate, tangeretin and pomegranate+tangeretin, respectively. Group V was DMBA-induced breast cancer-bearing rats, Group VI, VII and VIII also received simultaneously pomegranate, tangeretin and pomegranate+tangeretin, respectively, and also received a single dose of DMBA. The levels of malondialdehyde (MDA), as well as antioxidant enzyme activities of catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD) were measured in the plasma samples of rats. The plasma MDA level was found statistically significant higher in DMBA group (p = 0.001) and decreased significantly in all chemoprevention groups (p < 0.005). Plasma CAT, GPx, SOD activities were found decreased in Group V respect to control group. However; it was observed increases in whole prophylactic groups in respect to Group V. The most increases were found in Group VIII (for all enzyme activities). It was suggested that combination of Tangeretin and Pomegranate might have protective effect against DMBA-induced oxidative stress in breast cancer-bearing animals.
Keywords: Breast cancer; DMBA; Pomegranate; Tangeretin Breast cancer; DMBA; Pomegranate; Tangeretin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Gul, H.F.; Ilhan, N.; Susam, S.; Tatar, O.; Ilhan, N. Is There Any Protective Effect of Pomegranate and Tangeretin On The DMBA-Induced Rat Breast Cancer Model? Proceedings 2017, 1, 1025.

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