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Tomography, Volume 9, Issue 4
August 2023 - 28 articles
Cover Story: Image-based quantitative biomarkers are paramount for disease management, including MRI-based total kidney volume (TKV) for managing autosomal dominant polycystic kidney disease (ADPKD). However, ensuring accurate and reproducible TKV is a challenge. This study highlights inherent biases across different MRI pulse sequences in TKV measurement and uncovers the culprits for volume variations: breathing during scanning, varying breath-hold positions, and image composing errors. With deep-learning-assisted segmentation applied to all clinically routine MRI pulse sequences, outlier analysis becomes a powerful tool to ensure TKV accuracy. By emphasizing quality control and proactively addressing sequence biases, this research paves the way for consistent and clinically valuable MRI-based quantitative organ volume measurements. View this paper
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Tomography - ISSN 2379-139X