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Tomography, Volume 11, Issue 6

2025 June - 13 articles

Cover Story: This study investigates whether advanced CZT SPECT technology’s superior image quality translates to improved diagnostic accuracy for Alzheimer’s disease. We compared conventional SPECT (eCAM) with CZT SPECT in 29 patients with suspected neurodegenerative diseases. Despite CZT SPECT showing significantly higher gray matter/white matter contrast (1.615 vs. 1.458, p < 0.001), diagnostic accuracy for AD did not improve. Both participating clinicians experienced decreased sensitivity or specificity with CZT images. These findings reveal an important paradox: enhanced image clarity does not automatically enhance diagnostic performance, highlighting the need for specialized training to fully leverage advanced imaging technology in neurodegenerative disease diagnosis. View this paper
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